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A program of ITEST (Information Technology Experiences for Students and Teachers) funded by the National Science Foundation Background Session #4 Mutation,

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Presentation on theme: "A program of ITEST (Information Technology Experiences for Students and Teachers) funded by the National Science Foundation Background Session #4 Mutation,"— Presentation transcript:

1 A program of ITEST (Information Technology Experiences for Students and Teachers) funded by the National Science Foundation Background Session #4 Mutation, Natural Selection, Sequence Alignment, and Sequence Variation May 17, 2008 Dr. Simona Bartl Adjunct Professor Moss Landing Marine Labs

2 May 17th Workshop2 Mutation  Silent  Missense  Nonsense  Frameshift  Phenotype effects  http://www.youtub e.com/watch?v=kp 0esidDr-c http://www.youtub e.com/watch?v=kp 0esidDr-c Ref: evolution.berkeley.edu Ref: www.scienceclarified.com

3 May 17th Workshop3 Duplications  Gene  Chromosomal  Genome  Major role in evolution

4 May 17th Workshop4 Natural selection  The process by which organisms that are better suited to their environment than others produce more offspring. The American Heritage® Science Dictionary Copyright © 2005 Ref: www.wsu.edu

5 May 17th Workshop5 Sequence alignment www.acm.org  The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. www.biology-online.org

6 May 17th Workshop6 www.insectscience.org DNA sequence alignment

7 May 17th Workshop7 www.fieldmuseum.org

8 May 17th Workshop8 Protein sequence alignment www.rsc.org

9 May 17th Workshop9

10 10 Sequence variation  The location and degree of differences between nucleotide strings or amino acid strings  Most DNA sequence variants lie outside genes and may not effect phenotype but a fraction of the differences do lie within genes.  Usually variation in DNA sequences is greater than in protein sequences.

11 May 17th Workshop11 www-personal.umich.edu

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