1. A New Stereocontrolled Total Synthesis of the Mast Cell Inhibitory Alkaloid (+)-Monanchorin KarlJ.Hale* and Liping Wang. Org. Lett., 2014, 16 (7), xxxx Ailun Ma 2014. 4. 18

2. Author BSc University of London PhD University of London Chair of Organic and Medicinal Chemistry and Chemical Biology, Queen’s University Belfast Karl J. Hale

3. Introduction Isolation Isolated from the aqueous extract of the sponge Monanchora. Structure features A guanidine alkaloid with an unusual bicyclic skeleton, together with the known pentacyclic alkaloid crambescidin acid. Bioactivities Anti-cancer

4. Retrosynthesis

5. Initial Attempt at Preparing Aldehyde 4

6. A New Total Synthesis of (+)-Monanchorin

7. Conclusion They have developed a new and fully stereocontrolled asymmetric synthesis of the mast cell inhibitory alkaloid, (+)- monanchorin, that delivers this molecule as its TFA salt in high ee and high overall yield (7.2%,12steps).

8. Thank you