1. Experience with Using the UMLS Semantic Network to Coordinate Controlled Terminologies for a Large Clinical Data Repository James J. Cimino Department of Biomedical Informatics Columbia University College of Physicians and Surgeons National Library of Medicine, April 8, 2005

2. Overview Background History General principles Empiric observations: Semantic Network in the Medical Entities Dictionary Lessons to be learned

3. Clinical Data Architecture Central repository to collect data from myriad sources Myriad users of data - some not yet imagined

4. New York Presbyterian Hospital Clinical Information Systems Architecture Clinical Database Medical Entities Dictionary Database Monitor Medical Logic Modules Database Interface Research Administrative Alerts & Reminders Results Review... Radiology Laboratory Discharge Summaries Reformatter

5. Clinical Data Architecture Central repository to collect data from myriad sources Myriad users of data - some not yet imagined Patient-oriented, not visit oriented, database Relational, not hierarchical, model Entity-attribute-value model

6. Entity-Attribute-Value Clinical Data Repository

7. Clinical Data Architecture Central repository to collect data from myriad sources Myriad users of data - some not yet imagined Patient-oriented, not visit oriented, database Relational, not hierarchical, model Entity-attribute-value model Coded data wherever possible Unify terminology

8. Medical Entities Dictionary: A Central Terminology Repository

9. MED Structure Medical Entity Laboratory Procedure CHEM-7 Plasma Glucose Test Laboratory Specimen Plasma Specimen Substance Sampled Part of Has Specimen Event Laboratory Test Diagnostic Procedure Substance Measured Glucose Plasma Anatomic Substance Bioactive Substance Chemical Carbo- hydrate

10. Communicating Terminology Changes K#1 K#2 K#3 K#3 = 2.6 K#1 = 4.2 K#1 = 3.3 K#2 = 3.2 K#1 = 3.0

11. K#1 = 4.2 K#1 = 3.3 K#2 = 3.2 K#1 = 3.0 Solution: Hierarchical Integration K#1 K#2 K K#3 K#3 = 2.6

12. Use of the UMLS in Patient Care James J. Cimino, M.D. Center for Medical Informatics Columbia University Mont Pelerin, Switzerland 1994

13. UMLS Semantic Network Strict hierarchy Semantic types: 132 (135) Semantic relations: 46 (53) Inheritance of relations: 6233 (6700)

14. UMLS Metathesaurus Terms from 22 (100+) controlled vocabularies Total source terms: 311,046 Total strings: 279,237 (5,000,000) Total concepts: 152,444 (1,000,000) Relationships: 1,484,994 (16,000,000)

15. Medical Entities Dictionary Semantic Network Sources: 5 Strings: 108,492 Concepts: 35,281 Semantic relations: 23 pairs Semantic Links: 145,672

16. Comparisons - Methods CPMC Entities vs. UMLS Semantic Types MED Classes vs. UMLS Semantic Types MED Semantic Links vs. UMLS Semantic Relations MED Concepts vs. Metathesaurus Concepts MED Semantic Links vs. Meta Relations

17. Comparisons - Results DB EntitiesClassesLinks CPMC UMLSUMLS Types Relations Concepts Meta Links ++++ +++ +/- ++ +++

18. Summary Semantic Types provide good coverage Concepts provide good coverage in certain domains No technical reason why UMLS could not incorporate clinical vocabulary

19. Where We Are Today - Repository Patients: 2.6 million Visits: >10 million since 1996 with archives going back to 1979 Visit diagnoses, locations, procedures, providers, insurance Lab procedures: 16 million with 130 million results (to 1989) Radiology procedures reports: 5.7 million Pathology: 1.4 million Cardiology procedures: 1.5 million Resident signout notes:760,000 Operative Notes: 426,000 Clinical Notes: 400,000 Discharge Summaries: 420000 Medication orders: >60 million ObGyn Procedure Reports: 241,000 GI Procedure Reports: 101,000 Neurology Procedure Reports: 54,000 Ideatel BP’s: 215,000 Ideatel Glucose: 650,000 Consult Events: 18000 HEENT Events:13000 Hospitalist Notes:30000 PFT: 25000 Provider profiles 11000 IDX 1.4 million East Campus

20. Where We Are Today - MED Domains: 7++ (5) –HP lab terms –Misys lab terms –Cerner lab terms –Misys Radiology –Digimedix drugs –Cerner Drugs –ICD9-based problem list terms –Other applications –Knowledge terms Size: –Concept-based: 95,641 (35,281) –Multiple hierarchy: 141,306 –Synonyms: 239,581 (108,492) –Translations: 141,717 –Semantic link pairs: 52 (23) –Semantic links: 225,698 (145,672) –Attributes: 210,456

21. What does this have to do with the SN? MED was initially based on UMLS design (creationism) UMLS SN was the “starter set” MED is “local UMLS” for CPMC General principles were established MED has developed without further conscious attention to the SN (evolution) MED content represents real-world terminology What follows are empiric observations, open to criticism; perhaps indefensible

22. General Principles Everything is a class Multiple hierarchy Some relations are definitional At most, one part of relation pair is definitional Properties introduced at single points

23. Observations on the SN in the MED Arrangement of SN in MED Multiple hierarchy of STs Size of ST classes in MED (vs Meta?) STs as introduction points Intersections

24. UMLS Semantic Net in the MED A: T071: Medical Entity [94729]. +*A1.2: T017: Anatomical Structure [577].. A1.2.3: T021: Fully Formed Anatomical Structure [230]... A1.2.3.1: T023: Body Part, Organ, or Organ Component [204]... *A1.2.1: T018: Embryonic Structure [2]... *A1.2.2: T190: Anatomical Abnormality [20].... A1.2.2.1: T019: Congenital Abnormality [0].... A1.2.2.2: T020: Acquired Abnormality [18].. *A1.2.3.2: T024: Tissue [66].. *A1.2.3.3: T025: Cell [61].. *A1.2.3.4: T026: Cell Component [11].. *A1.2.3.5: T028: Gene or Genome [0].. *A1.4.2: T031: Body Substance [56].. +*A1.2.3.5: T028: Gene or Genome [0].. *A1.4.3: T168: Food [0]. A1: T072: Physical Object [5618].. +*A2.1.4.1: T022: Body System [65].. +*A2.1.5.1: T030: Body Space or Junction [43].. +*A2.1.5.2: T029: Body Location or Region [117.. A1.1: T001: Organism [3153]... A1.1.1: T002: Plant [1].... A1.1.1.1: T003: Alga [0]... A1.1.2: T004: Fungus [273]... A1.1.3: T005: Virus [169]... A1.1.4: T006: Rickettsia or Chlamydia [5]... A1.1.5: T007: Bacterium [992]... A1.1.6: T194: Archaeon [0]... A1.1.7: T008: Animal [93].... A1.1.7.1: T009: Invertebrate [85].... A1.1.7.2: T010: Vertebrate [6]..... A1.1.7.2.1: T011: Amphibian [0]..... A1.1.7.2.2: T012: Bird [0]..... A1.1.7.2.3: T013: Fish [0]..... A1.1.7.2.4: T014: Reptile [0]..... A1.1.7.2.5: T015: Mammal [1]...... A1.1.7.2.5.1: T016: Human [0].. A1.3: T073: Manufactured Object [16].... A1.3.1: T074: Medical Device [6].... A1.3.2: T075: Research Device [0].... A1.3.3: T200: Clinical Drug [0].. A1.4: T167: Substance [1942]... A1.4.1: T103: Chemical [1942].... A1.4.1.2: T104: Chemical Viewed Structurally [1115]..... A1.4.1.2.2: T197: Inorganic Chemical [81]..... A1.4.1.2.1: T109: Organic Chemical [1031]...... A1.4.1.2.1.9.1: T110: Steroid [68]...... A1.4.1.2.1.9.2: T111: Eicosanoid [3]...... A1.4.1.2.1.5: T114: Nucleic Acid, Nucleoside, or Nucleotide [32]...... A1.4.1.2.1.6: T115: Organophosphorus Compound [8]...... A1.4.1.2.1.7: T116: Amino Acid, Peptide, or Protein [250]....... +*A1.4.1.1.3.3: T126: Enzyme [61]...... A1.4.1.2.1.8: T118: Carbohydrate [55]...... A1.4.1.2.1.9: T119: Lipid [23]..... A1.4.1.2.3: T196: Element, Ion, or Isotope [24].... A1.4.1.1: T120: Chemical Viewed Functionally [1828]..... A1.4.1.1.1: T121: Pharmacologic Substance [1468]...... +*A1.4.1.1.3.4: T127: Vitamin [20]...... A1.4.1.1.1.1: T195: Antibiotic [130]..... A1.4.1.1.2: T122: Biomedical or Dental Material [9]..... A1.4.1.1.3: T123: Biologically Active Substance [530]...... A1.4.1.1.3.1: T124: Neuroreactive Substance or Biogenic Amine [13]...... A1.4.1.1.3.2: T125: Hormone [47]...... +A1.4.1.1.3.4: T127: Vitamin [20]...... +A1.4.1.1.3.3: T126: Enzyme [61]...... A1.4.1.1.3.5: T129: Immunologic Factor [268]...... A1.4.1.1.3.6: T192: Receptor [0]..... A1.4.1.1.4: T130: Indicator, Reagent, or Diagnostic Aid [30]..... A1.4.1.1.5: T131: Hazardous or Poisonous Substance [15] A: T071: Medical Entity [94729]. A2: T077: Conceptual Entity [77861].. A2.1: T078: Idea or Concept [378]... A2.1.1: T079: Temporal Concept [8]... A2.1.2: T080: Qualitative Concept [10]... A2.1.3: T081: Quantitative Concept [17]... A2.1.4: T169: Functional Concept [66].... +A2.1.4.1: T022: Body System [65]... A2.1.5: T082: Spatial Concept [190].... +A2.1.5.1: T030: Body Space or Junction [43].... +A2.1.5.2: T029: Body Location or Region [117].... *A2.1.5.3: T085: Molecular Sequence [15]..... A2.1.5.3.1: T086: Nucleotide Sequence [12]..... A2.1.5.3.2: T087: Amino Acid Sequence [0]..... A2.1.5.3.3: T088: Carbohydrate Sequence [0].... *A2.1.5.4: T083: Geographic Area [10].. A2.2: T033: Finding [12870]... A2.2.1: T034: Laboratory Finding or Test Result [12307]... A2.2.2: T184: Sign or Symptom [452].. A2.3: T032: Organism Attribute [8]... A2.3.1: T201: Clinical Attribute [2].. A2.4: T170: Intellectual Product [57821]... A2.4.1: T185: Classification [56057].... +*B2.2.1.2.1.1: T048: Mental or Behavioral Dysfunction [837]... A2.4.2: T089: Regulation or Law [0]... +*B1.3.1.3: T061: Therapeutic or Preventive Procedure [8316].. A2.5: T171: Language [0].. A2.6: T090: Occupation or Discipline [1]... A2.6.1: T091: Biomedical Occupation or Discipline [0].. A2.7: T092: Organization [3]... A2.7.1: T093: Health Care Related Organization [0]... A2.7.2: T094: Professional Society [0]... A2.7.3: T095: Self-Help or Relief Organization [0].. A2.8: T102: Group Attribute [124].. A2.9: T096: Group [27]... A2.9.1: T097: Professional or Occupational Group [0]... A2.9.2: T098: Population Group [9]... A2.9.3: T099: Family Group [1]... A2.9.4: T100: Age Group [0]... A2.9.5: T101: Patient or Disabled Group [0].. +*A1.2.1: T018: Embryonic Structure [2].. +*A1.2.2: T190: Anatomical Abnormality [20]... A1.2.2.1: T019: Congenital Abnormality [0]... A1.2.2.2: T020: Acquired Abnormality [18].. +*B2.2.1.2.1: T047: Disease or Syndrome [20498]... B2.2.1.2.1.1: T048: Mental or Behavioral Dysfunction [837]... B2.2.1.2.1.2: T191: Neoplastic Process [0] A: T071: Medical Entity [94729]. *B: T051: Event [55450].. B1: T052: Activity [32680]... B1.1: T053: Behavior [31].... B1.1.1: T054: Social Behavior [17].... B1.1.2: T055: Individual Behavior [12]... B1.2: T056: Daily or Recreational Activity [0]... B1.3: T057: Occupational Activity [32645].... B1.3.1: T058: Health Care Activity (Procedure) [32640]..... B1.3.1.1: T059: Laboratory Procedure [16676]..... B1.3.1.2: T060: Diagnostic Procedure [20567]..... +B1.3.1.3: T061: Therapeutic or Preventive Procedure [8316].... B1.3.2: T062: Research Activity [1]..... B1.3.2.1: T063: Molecular Biology Research Technique [0].... B1.3.3: T064: Governmental or Regulatory Activity [0].... B1.3.4: T065: Educational Activity [0]... B1.4: T066: Machine Activity [0].. B2: T067: Phenomenon or Process [20520]... B2.1: T068: Human-Caused Phenomenon or Process [1].... B2.1.1: T069: Environmental Effect of Humans [0]... B2.2: T070: Natural Phenomenon or Process [20516].... B2.2.1: T038: Biologic Function [20514]..... B2.2.1.1: T039: Physiologic Function [11]...... B2.2.1.1.1: T040: Organism Function [1]....... B2.2.1.1.1.1: T041: Mental Process [0]...... B2.2.1.1.2: T042: Organ or Tissue Function [5]...... B2.2.1.1.3: T043: Cell Function [0]...... B2.2.1.1.4: T044: Molecular Function [1]....... B2.2.1.1.4.1: T045: Genetic Function [0]..... B2.2.1.2: T046: Pathologic Function [20501]...... B2.2.1.2.3: T050: Experimental Model of Disease [0]...... +B2.2.1.2.1: T047: Disease or Syndrome [20498]....... B2.2.1.2.1.1: T048: Mental or Behavioral Dysfunction [837]....... B2.2.1.2.1.2: T191: Neoplastic Process [0]...... B2.2.1.2.2: T049: Cell or Molecular Dysfunction [0]... B2.3: T037: Injury or Poisoning [3778]

25. UMLS Semantic Net in the MED A: T071: Medical Entity [94729]. A1: T072: Physical Object [5618]. +*A1.2: T017: Anatomical Structure [577]. A2: T077: Conceptual Entity [77861]. *B: T051: Event [55450] Key: “A1.2”: UMLS Tree address “T071”: Semantic type ID “Event”: MED Name “+”: Multiple locations “*”: Discontinuous tree address “[577]”: Number of MED concepts

26. UMLS Semantic Net in the MED A: T071: Medical Entity [94729]. A1: T072: Physical Object [5618].. A1.1: T001: Organism [3153]... A1.1.1: T002: Plant [1].... A1.1.1.1: T003: Alga [0]... A1.1.2: T004: Fungus [273]... A1.1.3: T005: Virus [169]... A1.1.4: T006: Rickettsia or Chlamydia [5]... A1.1.5: T007: Bacterium [992]... A1.1.6: T194: Archaeon [0]... A1.1.7: T008: Animal [93].... A1.1.7.1: T009: Invertebrate [85].... A1.1.7.2: T010: Vertebrate [6]..... A1.1.7.2.1: T011: Amphibian [0]..... A1.1.7.2.2: T012: Bird [0]..... A1.1.7.2.3: T013: Fish [0]..... A1.1.7.2.4: T014: Reptile [0]..... A1.1.7.2.5: T015: Mammal [1]...... A1.1.7.2.5.1: T016: Human [0] Key: “A1.2”: UMLS Tree address “T071”: Semantic type ID “Event”: MED Name “+”: Multiple locations “*”: Discontinuous tree address “[577]”: Number of MED concepts

27. UMLS Semantic Net in the MED A: T071: Medical Entity [94729]. +*A1.2: T017: Anatomical Structure [577].. A1.2.3: T021: Fully Formed Anatomical Structure [230]... A1.2.3.1: T023: Body Part, Organ, or Organ Component [204]... *A1.2.1: T018: Embryonic Structure [2]... *A1.2.2: T190: Anatomical Abnormality [20].... A1.2.2.1: T019: Congenital Abnormality [0].... A1.2.2.2: T020: Acquired Abnormality [18].. *A1.2.3.2: T024: Tissue [66].. *A1.2.3.3: T025: Cell [61].. *A1.2.3.4: T026: Cell Component [11].. *A1.2.3.5: T028: Gene or Genome [0].. *A1.4.2: T031: Body Substance [56].. +*A2.1.4.1: T022: Body System [65].. +*A2.1.5.1: T030: Body Space or Junction [43].. +*A2.1.5.2: T029: Body Location or Region [117.. *A1.3: T073: Manufactured Object [16]... A1.3.1: T074: Medical Device [6]... A1.3.2: T075: Research Device [0]... A1.3.3: T200: Clinical Drug [0].. A1.4: T167: Substance [???]... A1.4.1: T103: Chemical [1942].... A1.4.1.1: T120: Chemical Viewed Functionally [1828]..... A1.4.1.1.1: T121: Pharmacologic Substance [1468]...... +*A1.4.1.1.3.4: T127: Vitamin [20]...... A1.4.1.1.1.1: T195: Antibiotic [130]..... A1.4.1.1.3: T123: Biologically Active Substance [530]...... +A1.4.1.1.3.4: T127: Vitamin [20] Key: “A1.2”: UMLS Tree address “T071”: Semantic type ID “Event”: MED Name “+”: Multiple locations “*”: Discontinuous tree address “[577]”: Number of MED concepts

28. 1: Medical Entirity [T071] MED-CODE UMLS-CODE NAME SUBCLASS-OF -> SUBCLASS (1: Medical Entity [T071]) SUBCLASS -> SUBCLASS-OF (1: Medical Entity [T071]) SYNONYMS PRINT-NAME HAS-PARTS -> PART-OF (1: Medical Entity [T071]) PART-OF -> HAS-PARTS (1: Medical Entity [T071]) DEFINITION MAIN-MESH SUPPLEMENTARY-MESH NAME-TOKEN DEFAULT-SHORT-DISPLAY-NAME DEFAULT-DISPLAY-NAME SPEECH-SYNONYM SPEECH-SYNTHESIS-NAME ENTITY-(HAS-RELATED)-PAGER-NUMBER ENTITY-(HAS)-MEDLEE-TARGET-TERM HIERARCHY-SELECTOR Property Introduction Points

29. 7: Body System [T022] ACTION-SITE-OF -> ACTION-SITE (98: Health Care Activity (Procedure) [T058]) 14: Anatomical Structure [T017] SITE-OF-PROBLEM -> HAS-PROBLEM-SITE (30007: Patient Problem) OBSERVATION-SITE-OF -> OBSERVATION-SITE (94: Diagnostic Procedure [T060]) 43: Chemical [T103] PHARMACEUTIC-COMPONENT-OF -> PHARMACEUTIC- COMPONENT (28103: Pharmacy Items (Drugs and Nondrugs)) 50: Measureable Entity MEASURED-BY-PROCEDURE -> ENTITY-MEASURED (64964: Assessment Procedures) LOINC-ANALYTE-NAME 76: Disease or Syndrome [C0391828] ETIOLOGY -> CAUSES-DISEASES (135: Etiologic Agent) IS-HISTORIC-DISEASE-FOR -> HISTORIC-DISEASE (56164: Factors Related to Past Disease Influencing Health Status) Medical Properties

30. 83: Laboratory Finding or Test Result [T034] RESULT-TYPE-->TESTS -> TEST-->RESULT-TYPE (94: Diagnostic Procedure [T060]) 86: Finding [T033] FINDING-(REFERS-TO)->ORGANISM 93: Laboratory Diagnostic Procedure COLLECTED-BY -> COLLECTED-FOR (33023: Specimen Collection [C0200345]) 94: Diagnostic Procedure [T060] UNITS TEST-->RESULT-TYPE -> RESULT-TYPE-->TESTS (83: Laboratory Finding or Test Result [T034]) OBSERVATION-SITE -> OBSERVATION-SITE-OF (14: Anatomical Structure [T017]) TEST-(HAS)-ABNORMAL-FLAG -> ABNORMAL-FLAG-(FOR)-TEST (77746: Abnormal Flag Value) 98: Health Care Activity (Procedure) [T058] PROCEDURE-(INDICATES)->PT-PROBLEM -> PT-PROBLEM- (INDICATED-BY)->PROCEDURE (30007: Patient Problem) ACTION-SITE -> ACTION-SITE-OF (7: Body System [T022]) Medical Properties

31. 135: Etiologic Agent CAUSES-DISEASES -> ETIOLOGY (76: Disease or Syndrome [C0391828]) 1181: Antibiotic Sensitivity Tests SENSITIVITY-ANALYTE -> SENSITIVITY-ANALYTE-OF (44440: Antibiotic or Bacterial Enzyme Inhibitor) 32291: Sampleable Entity SAMPLED-BY -> SYSTEM-SAMPLED (64970: Sample Entity) LOINC-SYSTEM-CODE 44440: Antibiotic or Bacterial Enzyme Inhibitor SENSITIVITY-ANALYTE-OF -> SENSITIVITY-ANALYTE (1181: Antibiotic Sensitivity Tests) Medical Properties

32. 59511: Clinical Repository Table TABLE-HAS-COLUMN -> COLUMN-IS-IN-TABLE (59512: Clinical Repository Column) 59512: Clinical Repository Column COLUMN-IS-IN-TABLE -> TABLE-HAS-COLUMN (59511: Clinical Repository Table) 59528: Generic Column COLUMN-HAS-PERMITTED-VALUES -> IS-PERMITTED-VALUE-FOR- COLUMN (67164: Verification Concept for Generic Column) 59729: Data Entry Form Component REPEAT-TYPE(DATA-ENTRY-COMPONENT) NUMBER-REPEATS(DATA-ENTRY-COMPONENT) REPEAT-LAYOUT-TYPE(DATA-ENTRY-COMPONENT) 59732: Form Field Allowable Values ALLOWABLE-VALUE-(FOR)->DATA-ENTRY-FIELD -> DATA-ENTRY- FIELD-(HAS)->ALLOWABLE-VALUE (42646: Data Entry Form Field) Data Dictionary Properties

33. 21762: ICD9 Element ICD9-CODE ICD9-ENTRY-CODE OLD-ICD9-CODE ICD9-NAME 23147: American Hospital Formulary Service Class AHFS-CLASS-CODE 28104: Drug Enforcement Administration (DEA) Controlled Substance Category DEA-CODE Controlled Terminology Properties

34. 1178: Number or String Result EVENT-ID-OF -> EVENT-ID (9876: CPMC Event) EVENT-PATIENT-ID-OF -> EVENT-PATIENT-ID (9876: CPMC Event) EVENT-ORGANIZATION-OF -> EVENT-ORGANIZATION (9876: CPMC Event) EVENT-LOCATION-OF -> EVENT-LOCATION (9876: CPMC Event) PARTICIPANT-ID-OF -> PARTICIPANT-ID (30352: Medical Event Participant) 9876: CPMC Event EVENT-ID -> EVENT-ID-OF (1178: Number or String Result) EVENT-DATE -> EVENT-DATE-OF (30349: Date Result) EVENT-PATIENT-ID -> EVENT-PATIENT-ID-OF (1178: Number or String Result) EVENT-PARTICIPANT -> PARTICIPANT-OF (30352: Medical Event Participant) EVENT-ORGANIZATION -> EVENT-ORGANIZATION-OF (1178: Number or String Result) EVENT-LOCATION -> EVENT-LOCATION-OF (1178: Number or String Result) EVENT-STATUS -> STATUS-OF (30355: CPMC Status Term) EVENT-(HAS)-ORGANIZATION -> ORGANIZATION-(FOR)-EVENT (81475: CPMC Coded Organizations) 30344: CPMC Order ORDER-QUANTITY -> ORDER-QUANTITY-OF (30350: Quantity Result) ORDER-FREQUENCY -> ORDER-FREQUENCY-OF (32504: Order Frequency) ORDER-START-DATE -> ORDER-START-DATE-OF (30349: Date Result) ORDER-STOP-DATE -> ORDER-STOP-DATE-OF (30349: Date Result) 30352: Medical Event Participant PARTICIPANT-OF -> EVENT-PARTICIPANT (9876: CPMC Event) PARTICIPANT-ID -> PARTICIPANT-ID-OF (1178: Number or String Result) PARTICIPANT-NAME -> PARTICIPANT-NAME-OF (32653: ID Number Plus Text Result) Data Modeling Properties

35. 40441: Display Information [C0010996] DEFAULT-DISPLAY-FOR -> HAS-DEFAULT-DISPLAYS (94: Diagnostic Procedure [T060]) DISPLAYS-ELEMENTS-OF -> ELEMENTS-DISPLAYED-BY (94: Diagnostic Procedure [T060]) HAS-DISPLAY-PARAMETERS -> IS-DISPLAY-PARAMETER-OF (94: Diagnostic Procedure [T060]) DISPLAY-PARAMETER-ORDER Application Properties

36. 42645: Data Entry Form FORM-(IS-PART-OF)->FORMSET -> FORMSET-(CONTAINS)->FORM (66436: Data Entry Form Sets) 42646: Data Entry Form Field DATA-ENTRY-FIELD-(HAS)->ALLOWABLE-VALUE -> ALLOWABLE-VALUE- (FOR)->DATA-ENTRY-FIELD (59732: Form Field Allowable Values) FORM-FIELD-(HAS)->FIELD-TYPE -> FIELD-TYPE-(FOR)->FORM-FIELD (66295: Data Entry Field Type) FORM-FIELD-(OBEYS)->PREFILL-RULE -> PREFILL-RULE-(FOR)->FORM- FIELD (66311: Prefill Rules) FORM-FIELD-MAXIMUM-VALUE FORM-FIELD-MINIMUM-VALUE FORM-FIELD-MAXIMUM-CHARACTER-COUNT 59732: Form Field Allowable Values ALLOWABLE-VALUE-(FOR)->DATA-ENTRY-FIELD -> DATA-ENTRY-FIELD- (HAS)->ALLOWABLE-VALUE (42646: Data Entry Form Field) 66295: Data Entry Field Type FIELD-TYPE-(FOR)->FORM-FIELD -> FORM-FIELD-(HAS)->FIELD-TYPE (42646: Data Entry Form Field) 66308: Layout Type LAYOUT-TYPE-(FOR)->FORM-STRUCTURE -> FORM-STRUCTURE-(HAS)- >LAYOUT-TYPE (66405: Data Entry Form Structure) Document Properties

37. 43: Chemical [T103] 50: Measureable Entity 135: Etiologic Agent 1780 cases. 50: Measureable Entity 83: Laboratory Finding or Test Result [T034] 86: Finding [T033] 135: Etiologic Agent 315: Microbiology Result 30007: Patient Problem 35878: Laboratory Results 1399 cases. 83: Laboratory Finding or Test Result [T034] 86: Finding [T033] 30007: Patient Problem 35878: Laboratory Results 3309 cases. 83: Laboratory Finding or Test Result [T034] 86: Finding [T033] 30007: Patient Problem 35878: Laboratory Results 52243: New York Hospital (NYH) Laboratory Nomenclature Term 1601 cases. 207 Intersection Classes

38. 83: Laboratory Finding or Test Result [T034] 86: Finding [T033] 30007: Patient Problem 52243: New York Hospital (NYH) Laboratory Nomenclature Term 2906 cases. 93: Laboratory Diagnostic Procedure 94: Diagnostic Procedure [T060] 98: Health Care Activity (Procedure) [T058] 111: Event [T051] 144: Laboratory Diagnostic Batteries 2248: Single-Result Laboratory Test 49999: New York Hospital (NYH) Laboratory Concept 64964: Assessment Procedures 1197 cases. 93: Laboratory Diagnostic Procedure 94: Diagnostic Procedure [T060] 98: Health Care Activity (Procedure) [T058] 111: Event [T051] 144: Laboratory Diagnostic Batteries 49999: New York Hospital (NYH) Laboratory Concept 64964: Assessment Procedures 1822 cases. 207 Intersection Classes

39. 93: Laboratory Diagnostic Procedure 94: Diagnostic Procedure [T060] 98: Health Care Activity (Procedure) [T058] 111: Event [T051] 2248: Single-Result Laboratory Test 49999: New York Hospital (NYH) Laboratory Concept 64964: Assessment Procedures 3200 cases. 93: Laboratory Diagnostic Procedure 94: Diagnostic Procedure [T060] 98: Health Care Activity (Procedure) [T058] 111: Event [T051] 2248: Single-Result Laboratory Test 50000: CPMC Single-Result Laboratory Test 64964: Assessment Procedures 3197 cases. 98: Health Care Activity (Procedure) [T058] 111: Event [T051] 21762: ICD9 Element 67164: Verification Concept for Generic Column 10048 cases. 207 Intersection Classes

40. Revisiting Recommendations - General Make “Event” a temporal concept Conceptual vs. Physical polarization Directed Acyclic Graph Merge Network and Metathesaurus

41. Revisiting Recommendations - Specific Tests have Specimens Tests have Parts Separate Medications from Chemicals Liberalize assignment of Relations

42. Revisiting Summary Semantic Types provide good coverage Concepts provide good coverage in certain domains No technical reason why UMLS could not incorporate clinical vocabulary

43. Lessons to be Learned The MED is representative of clinical care MED classes work well as introduction points Multiple hierarchy works Semantic Network is largely intact Unifying organization for anatomy needed Further study of MED will suggest additional types and relations