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Published byBertram Garrett Modified over 9 years ago
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Cultured in vitro human autologous epidermis for clinical applications Justyna Drukała Laboratory of Cell and Tissue Engineering Department of Cell Biology Faculty of Biochemistry, Biophysics & Biotechnology Jagiellonian University
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Skin-replecement product technology
0.5 cm2 patients own skin biopsy epidermal cells culturing in vitro prepared cells transplanted back on to the same patient in an injectable fibrin matrix after 2 weeks of in vitro cell culture applicated cells are capable of dividing with high growth potential, form growing epidermal islands in wound bed
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Primary culture of epidermal cells after enzymatic dissociation
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Posibilities of our method utilization
This skin-replacement product is designed to meet the needs mainly of the chronic ulcers and burns care
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Keratinocytes cell suspension
3 weeks after Keratinocytes cell suspension in fibrin-glue cells transplantation 3 months after
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Technology advantages
no rejection by patient – permanent wound covering no adverse reactions in the clinic no associated infections no risk of disease transmission significantly better wound closure efficancy in non-healing wounds than by using conventional noninvasive methods scarless wound healing
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Other skin-repacement matherials
Split-skin autotransplantation (require substantially large skin flaps – under general anesthesis) Allografts or other biological dressing - temporal wound covering
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Current status development of strategic alliances for the promotion of the product searching for substantial funding for the venture
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