1. CHAPTER 6 HOMOGRAFT - HEART VALVE TRANSPLANTATION Editor: Mr Mohamed Ezani Md. Taib Expert Panel: Mr Mohamed Ezani Md. Taib (Chairperson) Dr Abdul Rais Sanusi Datuk Dr Aizai Azan Abdul Rahim Dr Ashari Yunus Dato’ Dr David Chew Soon Ping

2. Table 6.1.1: Stock and Flow, 1996-2008 Year 1996199719981999200020012002200320042005200620072008 New transplant 432221713202221934528 Deaths* 1043064342103 Lost to follow up 0000000000000 Alive with functioning graft at 31 st December 33553678094112130135136139144168 Figure 6.1.1: Stock and Flow, 1996-2008 Number of patients Year 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 New patients Alive at 31st Dec 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

3. Table 6.2.1: Distribution of Patients by Gender, 1996-2008 Year1996199719981999200020012002200320042005200620072008TOTAL GenderNo. Male21999106914304213100 Female213 8314137630315100 TOTAL432221713202221934528200 Figure 6.2.1: Distribution of Patients by Gender, 1996-2008 Number Year 0 2 4 6 8 10 12 14 16 18 20 Male Female 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

4. Table 6.2.2: Distribution of Patients by Ethnic Group, 1996-2008 Year1996199719981999200020012002200320042005200620072008TOTAL Ethnic groupNo. Malay1191599101612632318123 Chinese3114329461010751 Indian022201221010114 Others001320011002212 TOTAL432221713202221934528200 Figure 6.2.2: Distribution of Patients by Ethnic Group, 1996-2008 Number Year 0 2 4 6 8 10 12 14 16 18 20 Malay Chinese Indian Others 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

5. Table 6.2.3: Distribution of Patients by Age, 1996-2008 Year1996199719981999200020012002200320042005200620072008TOTAL Age groupNo. 0-9 215 1210141011313219117 10-19 11355221084012760 20-39 141003211200217 40-59 00000101100104 ≥60 00101000000002 TOTAL 432221713202221934528200 Mean 1211 71211101215 616711 SD 771541714611 8518610 Median 11108785 9 2051178 Min 53 months 125 months325614 months1 months Max 2130701767532853422012472170 Figure 6.2.3: Distribution of Patients by Age, 1996-2008 Number Year 0 2 4 6 8 10 12 14 16 18 20 0-9 years 10-19 years 20-39 years 40-59 years ≥60 years 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

6. Table 6.3.1: Number of Valves Harvested by Type of Homograft, 1996-2008 Year1996199719981999200020012002200320042005200620072008TOTAL Type of homograftNo. Aortic81710811141087514915136 Pulmonary114111012 1498515813132 TOTAL9312118232624171510291728268 Table 6.3.2: Type of Transplant, 1996-2008 Year 1996199719981999200020012002200320042005200620072008TOTAL Type of transplant No. Aortic 4191177910 4112893 Pulmonary 01311106111211523320107 TOTAL 432221713202221934528200 Figure 6.3.2: Type of Transplant, 1996-2008 Number Year 0 2 4 6 8 10 12 14 16 18 20 22 Aortic Pulmonary 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

7. Table 6.4.1: Patient Survival by Gender, 1996-2008 GenderMaleFemale Interval (years)% SurvivalSE% SurvivalSE 1923893 3 3864 5874864 Figure 6.4.1: Patient Survival by Gender, 1996-2008

8. Table 6.4.2: Patient Survival by Age Group, 1996-2008 Age group0-9 years10-19 years≥20 years Interval (months)% SurvivalSE% SurvivalSE% SurvivalSE 1883972858 3873914809 58738947410 Figure 6.4.2: Patient Survival by Age Group, 1996-2008

9. Table 6.4.3: Patient Survival by Type of Homograft, 1996-2008 Type of homograftAorticPulmonary Interval (years)% SurvivalSE% SurvivalSE 1903913 3854903 5844893 Figure 6.4.3: Patient Survival by Type of Homograft, 1996-2008