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Entomophthoromycosis caused by Basidiobolus.

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Presentation on theme: "Entomophthoromycosis caused by Basidiobolus."— Presentation transcript:

1 Entomophthoromycosis caused by Basidiobolus.
A chronic inflammatory or granulomatous disease generally restricted to the limbs, chest, back or buttocks primarily occurring in children with predominance in males. Initially, lesions appear as subcutaneous nodules, which develop into massive, firm, indurated, painless swellings, which are freely movable over the underlying muscle but are attached to the skin which is hyperpigmented but not ulcerated. Distribution: Tropical Africa, India, Indonesia and South East Asia including the Northern Territory of Australia. Aetiological Agent: Basidiobolus ranarum (= B. haptosporus) commonly present in decaying fruit and vegetable matter, and as a commensal in the intestinal tract of frogs, toads and lizards. Text slide.

2 454. Entomophthoromycosis caused by Basidiobolus ranarum showing a subcutaneous lesion involving the entire thigh and buttock of an Indonesian boy. There was a secondary bacterial infection following a biopsy. (Courtesy of Dr J.W. Rippon, University of Chicago, USA). 454

3 455. Entomophthoromycosis caused by Basidiobolus ranarum showing an ulcerated subcutaneous lesions on the abdomen of a young boy from Darwin. 455

4 456. Entomophthoromycosis caused by Basidiobolus ranarum showing an ulcerated subcutaneous lesions on the abdomen of a young boy from Darwin. 456

5 457. Haematoxylin and eosin (H&E) stained section of tissue from a lesion on a child's arm showing broad septate hyphae surrounded by an eosinophilic sheath (Splenodore-Hoeppli phenomenon) typical of Entomophthoromycosis. Note there are two major histological differences between subcutaneous zygomycosis caused by Basidiobolus and Conidiobolus (Entomophthoromycosis) and zygomycosis caused by members of the Mucorales (mucormycosis). Firstly, in Entomophthoromycosis the hyphae are surrounded by an eosinophilic sheath and there is a lack of vascular invasion, which is so characteristic of infections caused by the Mucorales. Secondly, the hyphal elements of Mucorales are sparsely septate in tissue, where as frequent septation is seen in tissue hyphae of Basidiobolus or Conidiobolus. 457

6 458. Basidiobolus ranarum on Sabouraud's dextrose agar after 17 days incubation at 26OC showing a flat, yellowish-grey, glabrous, radially folded colony covered by a fine, powdery, white surface mycelium. Note the satellite colonies formed by germinating conidia ejected from the primary colony. 458

7 459. Microscopic morphology of Basidiobolus ranarum showing globose, one-celled conidia that are forcibly discharged from a sporophore. The sporophore has a distinct swollen area just below the spore that actively participates in the discharge of the spore. 459

8 460. Microscopic morphology of Basidiobolus ranarum showing numerous round, smooth, thick-walled zygospores. 460


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