1. Critical Care Department St. Michael’s Hospital Research Program © 2003 Critical Care Dept, St. Michael’s Hospital

2. Rationale Improve quality of care Improve quality of care Enhance scientific knowledge Enhance scientific knowledge Develop specific expertise Develop specific expertise Design a specialty Design a specialty © 2003 Critical Care Dept, St. Michael’s Hospital

3. Critical care Genes Genes DNA DNA mRNA mRNA Proteins level Proteins level Proteins activity Proteins activity Environment Pathogens Underlying disease Therapy © 2003 Critical Care Dept, St. Michael’s Hospital

4. Continuous Quality Improvement Education Clinical Services Research & Development © 2003 Critical Care Dept, St. Michael’s Hospital

5. Previous Model Translational Research Basic Science Clinical Research © 2003 Critical Care Dept, St. Michael’s Hospital

6. Our Model Basic Science Clinical Research Translational Research © 2003 Critical Care Dept, St. Michael’s Hospital