1. PRECONCEPTION COUNSELING AND CARE FOR HIV-INFECTED WOMEN OF CHILDBEARING AGE

2. Preconception Counseling and Care (1)  Preconception care is part of routine primary care and is recommended by the CDC, ACOG, and other national organizations.  Purpose:  Prevention of unintended pregnancies  Optimization of maternal health prior to pregnancy  Prevention of perinatal transmission  Prevention of HIV transmission to an uninfected partner while trying to conceive August 2012 2 www.aidsetc.org

3. Preconception Counseling and Care (2) Recommendations  Discuss childbearing intentions with all women of childbearing age on an ongoing basis throughout the course of their care. (AIII)  Include information about effective and appropriate contraceptive methods. (AI)  Preconception counseling: Include information on safer sex and elimination of alcohol, illicit drugs, and smoking. (AII) August 2012 3 www.aidsetc.org

4. Preconception Counseling and Care (3)  Include assessment of HIV disease status and need for ART for the health of the woman. (AII)  Choose an ART regimen for HIV-infected women of childbearing age based on:  Efficacy  Hepatitis B status  Teratogenic potential  Possible adverse outcomes for mother and fetus (AII) August 2012 4 www.aidsetc.org

5. Reproductive Options for HIV-Concordant and Serodiscordant Couples (1) All couples:  Both partners should be screened for genital tract infections. (AII)  Semen analysis is recommended for HIV- infected men. HIV, and possibly ART, may be associated with a higher prevalence of abnormalities. August 2012 5 www.aidsetc.org

6. Reproductive Options for HIV-Concordant and Serodiscordant Couples (2) Serodiscordant couples:  Expert consultation is recommended. (AIII)  No single method of safer conception is fully protective against transmission of HIV.  Initiation of ART for the HIV-infected partner is recommended (AI for CD4 counts ≤550 cells/µL and BIII for CD4 counts >550 cells/µL).  Maximal viral suppression is recommended before attempting conception. (AIII)  HPTN 052 trial showed ART can significantly decrease HIV transmission to uninfected partners. August 2012 6 www.aidsetc.org

7. Reproductive Options for HIV-Concordant and Serodiscordant Couples (3)  HIV-infected female with uninfected male partner: The safest option is artificial insemination, including the option of self- insemination, during the periovulatory period. (AIII)  HIV-infected man with uninfected female: Sperm preparation techniques + either intrauterine insemination or in vitro fertilization should be considered if using donor sperm from an uninfected male is unacceptable. (AII) August 2012 7 www.aidsetc.org

8. Reproductive Options for HIV-Concordant and Serodiscordant Couples (4)  Periconception administration of PrEP for HIV- uninfected partners may offer an additional tool to reduce the risk of sexual transmission. (CIII)  The utility of PrEP of the uninfected partner when the infected partner is receiving ART has not been studied.  Outcome studies are needed to examine adverse events, including risk of congenital abnormalities. August 2012 8 www.aidsetc.org