1. The organization of the nervous system

2. Structure of the human cerebral cortex

3. Sensory map

4. Structure of the human cerebral cortex Motor map

5. Neuromuscular junction

6. How to manipulate it ? Curare ACh-ase inhibitors Myastenia gravis Botulinum toxin Pesticides

7. Parkinson’s disease Basal ganglia Parkinson’s disease Basal ganglia

8. Parkinson’s disease Most common symptoms Parkinson’s disease Most common symptoms Shaking (tremor) at Rest Stiffness (rigidity) Slow Movement (bradykinesia) Balance Problems (postural instability)

9. Multiple sclerosis Myelin

10. Multiple sclerosis Demyelination

11. Multiple sclerosis Progression Multiple sclerosis Progression

12. AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) Mutation or defect in neuronal SOD activity Excess oxidative stress to neuronal mitochondria Degeneration of motor neurons Paralysis – muscular atrophy Exacerbated by glutamate neurotransmitter activity