1. Hemorrhagic Fever Virus

2. Hemorrhagic Fever Virus
A group of viruses which are transmitted by rodents or arthropods cause viral hemorrhagic fever.

3. Hemorrhagic Fever Virus
Bunyaviridae family
Hantavirus
Crimean-Congo hemorrhagic fever virus (CCHFV)
(OR Xinjiang hemorrhagic fever virus, XHFV)
Flaviviridae Family
Dengue virus

4. Hantavirus HFRS (hemorrhagic fever with renal syndrome) HPS
(hantavirus pulmonary syndrome)

5. Biological Properties
spherical, oval, polymorphic
120nm in diameter on average
envelope
-ssRNA, 3 segments

6. Pathogenicity source: rodents, especially rats transmission route
respiratory tract
gastrointestinal tract
contact: direct contact, bite
vertical route
arthropod transmission

7. Pathogenicity Pathogenesis damage of small blood vessels
different in the major organs

8. Pathogenicity Clinical Findings HFRS HPS
typical symptoms: fever, hemorrhage, kidney damage
HPS
Early symptoms: fatigue, fever and muscle aches
Late symptoms: coughing and shortness of breath, lungs fill with fluid.

9. Dengue virus

10. hantavirus