1. © Cancer Research UK 2005 Registered charity number 1089464 Oesophagus Cancer The statistics in this presentation are based on the Oesophagus CancerStats report published in 2007. However, the incidence, mortality and survival statistics have been updated to reflect the latest available data. For more information about UK cancer statistics please contact stats.team@cancer.org.uk or visit http://info.cancerresearchuk.org/cancerstats stats.team@cancer.org.ukhttp://info.cancerresearchuk.org/cancerstats

2. © Cancer Research UK 2005 Registered charity number 1089464 Figure One: Diagram of oesophagus

3. © Cancer Research UK 2005 Registered charity number 1089464 Figure Two:Numbers of new cases and age-specific incidence rates by sex, cancer of the oesophagus, UK 2006

4. © Cancer Research UK 2005 Registered charity number 1089464 Table One: Numbers and rates of new cases of oesophageal cancer, UK, by country, 2006 EnglandWalesScotlandN.IrelandUK Cases Males4,0873065201215,034 Females2,266160308562,790 Persons6,3534668281777,824 Crude rate per 100,000 population Males16.421.221.114.217.0 Females8.810.511.66.39.0 Persons12.515.716.210.212.9 Age-standardised rate (European) per 100,000 population Males13.616.017.313.614.1 95% CI13.214.014.217.715.818.811.216.013.714.4 Females5.56.46.95.05.7 95% CI5.35.75.47.46.17.73.76.35.45.9 Persons9.310.811.68.89.5 95% CI9.09.59.811.710.812.47.510.19.39.7

5. © Cancer Research UK 2005 Registered charity number 1089464 Figure Three: World age standardised incidence rates for oesophageal cancer, 2002 estimates

6. © Cancer Research UK 2005 Registered charity number 1089464 Figure Four (a): Age-standardised (European) incidence rates, oesophageal cancer, EU countries, 2002 estimates

7. © Cancer Research UK 2005 Registered charity number 1089464 Figure Five: Age-standardised (European) incidence rates, oesophageal cancer, by sex, Great Britain, 1975-2006

8. © Cancer Research UK 2005 Registered charity number 1089464 Figure Eight: The effect of tobacco smoking, alcohol and bodyweight on the risk of SCC and AC of the oesophagus Adapted with permission from OUP

9. © Cancer Research UK 2005 Registered charity number 1089464 Table Two: Clinical risk factors for Barrett’s metaplasia and associated adenocarcinoma

10. © Cancer Research UK 2005 Registered charity number 1089464 Table Three: Polymorphisms and genes associated with oesophageal cancer

11. © Cancer Research UK 2005 Registered charity number 1089464 Figure Nine: Apoptosis and adhesion in progression of Barrett’s metaplasia

12. © Cancer Research UK 2005 Registered charity number 1089464 Figure Ten: Five and ten year relative age standardised survival for oesophageal cancer patients aged 15-99, England and Wales, 1971-2001

13. © Cancer Research UK 2005 Registered charity number 1089464 Figure Eleven: Five-year relative survival for patients diagnosed with oesophageal cancer in England and Wales during 1986-1990 by age at diagnosis

14. © Cancer Research UK 2005 Registered charity number 1089464 Table Four: Numbers and rates of death, oesophageal cancer, UK by country, 2007 EnglandWalesScotlandN.IrelandUK Deaths Males3,9093094851024,805 Females2,044149301542,548 Persons5,9534587861567,353 Crude rate per 100,000 population Males15.621.319.511.816.1 Females7.99.811.36.08.2 Persons11.715.415.38.912.1 Age-standardised rate (European) per 100,000 population Males12.615.815.511.313.0 CI 95%12.213.014.117.614.116.99.113.512.613.3 Females4.65.66.54.34.8 CI 95%4.44.84.76.55.87.23.25.54.75.0 Persons8.310.310.57.38.6 CI 95%8.18.59.411.39.811.36.18.4 8.8

15. © Cancer Research UK 2005 Registered charity number 1089464 Figure Twelve: European age standardised mortality rates oesophageal cancer, England & Wales, and Scotland, by sex, 1971-2003