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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD
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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Aim – Investigate effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. Relevance – SCI-induced osteoporosis is most rapid and severe form of osteoporosis. – Pulsed electromagnetic field therapy is reported to promote peripheral nerve regeneration, osteogenesis, and SCI recovery.
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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Method Adult Wistar rats were equally divided into 3 groups: – SCI and SCI+MF: complete spinal cord transection. – Sham: laminectomy only. 1 d post-SCI: exposed to ELF-MF or sham exposed. Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. All rats were sacrificed 8 wk post-SCI: – Tibias and femurs were isolated for bone mineral content (BMC), bone mineral density (BMD), and biochemical status analyses.
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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Results BBB score decreased post-SCI, which partially recovered after ELF-MF. SCI rats (vs sham): – Statistically significant decrease in BMC, calcium, phosphorus, carbon, BMD, and biochemical level, which attenuated in SCI+MF rats except carbon content. Electron microscopic study revealed enhanced microstructural composition and compactness in cortical and trabecular parts of treated bones.
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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Example of spinal cord 8 wk post-SCI in SCI and SCI+MF rats. Note areas of continuity in spinal cord and smaller cavities vis-à- vis degeneration of neurons (arrow mark) in SCI+MF vs SCI group.
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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. http://dx.doi.org/10.1682/JRRD.2011.12.0248 Slideshow Project DOI:10.1682/JRRD. 2011.12.0248JSP Conclusion Results suggest that chronic ELF-MF exposure to SCI rats effectively attenuates SCI-induced osteoporosis.
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