1. Improving Cancer Outcomes for African-Americans New Hanover Regional Medical Center Coastal Area Health Education Center University of North Carolina at Chapel Hill University of North Carolina at Wilmington Report given at the Program Steering Committee Meeting 22 June 2006, Toronto

2. Yearly Patient Accruals and Total Enrollment Clinical Trials (through Apr 2006) 2003200420052006total # 0913122 #(%) black 2(22)4(31)06(26)

3. Yearly Patient Accruals and Total Enrollment Navigated Patients (through Apr 2006) 2003200420052006total # 05432573 #(%) black 4(80)33(77)14(56)51(70)

4. Yearly Patient Accruals and Total Enrollment Psychological Study (closed 2005) 2003200420052006total # 089171na260 #(%) black 28 (31) 93 (54) 121 (47)

5. Status of Clinical Trials Head & Neck trial Hyperfractionated IMR with weekly concurrent Cisplatin First investigator-initiated clinical trial at NHRMC 17 patients enrolled (3 black) Good early outcomes Treatment efficacy Potentially less toxicity

6. Additional Clinical Trials Small cell lung ca – Chemo plus chest radiotherapy Ca of anal canal – Chemo + radiotherapy Prostate Ca (RTOG 0232) – External beam plus brachytherapy versus brachytherapy alone (enrolled one black male in June)

7. Additional Clinical Trials Non-small cell lung ca – Cranial irradiation vs observation Non-small cell lung ca – Selenium supplementation Pancreatic ca (NSABP)– Chemo + radiotherapy vs chemo DCIS (NSABP) – Anastrozole vs Tamoxifen

8. Peer-reviewed Publications Manuscripts in preparation Maguire, Hamann, Menon Prostate cancer risk groups and treatment choices (ASTRO poster) Maguire Treatment planning using TELESYNERGY ® (ATA presentation) Hamann, Mathews, Johnson Effects of cancer on cultural and social beliefs and attitudes (ASTRO poster)

9. Peer-reviewed Publications Manuscripts in preparation, cont’d Kotwall, Maguire, Dobson, Hamann Racial differences in rectal cancer outcomes Kotwall, Cyr Racial differences in frequency of breast conservation surgery and breast reconstruction in women with Stages 0,1,& 2 breast cancer

10. Partnership Relations UNC-Chapel Hill visits to Chapel Hill by PI educational conferences patient consultations Second site for Head & Neck trial

11. TELESYNERGY ® Use Educational conferences Treatment planning Meetings Two papers at ATA, May 2006 Honaker, Maguire, Rosenman A Year & a half of TELESYNERGY® in southeastern NC Maguire TELESYNERGY®: Bridging academic and community radiology oncology treatment planning

12. Patient Navigator Program Active recruitment of patients Heavy schedule of outreach events Partnered with Prostate Cancer Screening project Staffing 2 ftes 2 volunteers Products Video brochure

13. Status of Psychological Research Conducted 260 interviews Analyzed 228 interviews Interventions based on results Web-based curriculum modules for MDs Clergy Day on Cancer Pending proposal Increasing the Utilization and Impact of the NCI’s Cancer Information Service