2. Welcome To the future of Ocular TB, To the future of collaboration

3. COTS: Brief International encrypted cloud-based registry for Ocular Tuberculosis 1 st international registry for Ocular Tuberculosis 1 st attempt to use an encrypted cloud-based platform for medical study

4. Why Ocular TB TB estimated prevalence of 1/3 of the Worlds population Reports of Ocular involvement in 1-2% of all patients with Systemic TB Presentations are diverse without accepted diagnostic criteria Lack of practical and reliable diagnostic tests

5. Aims Collect good quality data to support reproducible recommendations Clarify clinical evaluation and management of Ocular TB

6. Methods - Team IDSite Name 001Advanced Eye Centre, PGIMER 002Moorfields Eye Hospital, London 003Tan Tock Seng Hospital, Singapore 004Singapore National Eye Centre 005Aravind Eye Care, India 006Narayana Nethrayala, India 007LV Prasad Eye Institute, India 008Sankara Nethrayala, India 009Prabha Eye Institute, India IDSite Name 010Shroff Eye Centre, India 011University of Manchester, UK 012University of Monstair, Turkey 013La Source Eye Centre, Laussane 014Save Sight Institute, Sydney 015King Khaled Eye Hospital, Riyadh 016Luigi Hospital Milan, Italy 017Rio de Janeiro, Brazil 018Pierre and Marie Curie University, Paris IDSite Name 019University of Istanbul, Turkey 020University of Thessaloniki, Greece 021Northwestern University, Chicago 022LVPEI Bhubaneswar, India 023Marche-Ancona University, Italy 024Dr Shroff’s Charity Eye Hospital, New Delhi 025Ramon y Cajal University Hospital, Spain 027UNMC, Nebraska, USA

7. Methods – Web-based Data collection Real-time updates of primary data set Interactive platform programmed as a smart form Compulsory data points Smart phone optimisation – data entry via convenience of smartphones

9. Methods – Data protection Patient confidentiality – no patient Identifiers One-way site traffic into the Data set, preventing file corruption by viruses Entire data set saved and stored securely at regular intervals

10. Methods - Recruitment Inclusion criteria Patient records from initial presentation to at least 1 year follow-up Results of supporting ancillary investigations Minimum of 1 year follow-up (for COTS-I, between Jan’05 – April’14) Diagnosis of presumed ocular tuberculosis – satisfying this criteria: Clinical signs suggestive of ocular TB Investigations documenting the mycobacterium/ its genome Corroborative investigations Exclusion of other Uveitis Entities Exclusion criteria: Ocular co-morbidities interfering with media clarity

11. Authorship policies Meeting presentations Primary Manuscripts Secondary Manuscripts

12. Thank you Please feel free to ask any questions We look forward to this meaningful collaboration with you.