1. Inquiry into Life Twelfth Edition Chapter 4 Lecture PowerPoint to accompany Sylvia S. Mader Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. 4.1 Plasma Membrane Structure and Function Regulates the entrance and exit of molecules into and out of the cell Phospholipid bilayer with embedded proteins –Hydrophilic polar heads –Hydrophobic nonpolar tails –Cholesterol (animal cells)

3. Fluid-mosaic Model of Plasma Membrane Structure

4. 4.1 Plasma Membrane Structure and Function Types of Membrane Proteins –Channel Proteins –Carrier Proteins –Cell Recognition Proteins –Receptor Proteins –Enzymatic

5. A Proteins

6. 4.2 Permeability of the Plasma Membrane Differentially (selectively) Permeable Factors that determine how a substance may be transported across a plasma membrane: –Size –Polar or Nonpolar

7. How Molecules Cross the Plasma Membrane

8. Passage of Molecules into and out of the Cell

9. 4.2 Permeability of the Plasma Membrane Diffusion and Osmosis

10. 4.2 Permeability of the Plasma Membrane Diffusion and Osmosis –Diffusion is the movement of molecules from an area of higher to lower concentration

11. Process of Diffusion

12. 4.2 Permeability of the Plasma Membrane Diffusion and Osmosis –Diffusion is the movement of molecules from an area of higher to lower concentration –Oxygen and Carbon Dioxide are two gases that can diffuse through the plasma membrane

13. Gas Exchange in Lungs

14. 4.2 Permeability of the Plasma Membrane Osmosis –Osmosis is the diffusion of water across a differentially permeable membrane.

15. 4.2 Permeability of the Plasma Membrane Osmosis –Osmosis is the diffusion of water across a differentially permeable membrane. –Osmotic pressure is the pressure that develops in a system due to osmosis.

16. Osmosis Demonstration

17. 4.2 Permeability of the Plasma Membrane Osmosis –Isotonic:the solute concentration is equal inside and outside of a cell

18. 4.2 Permeability of the Plasma Membrane Osmosis –Isotonic:the solute concentration is equal inside and outside of a cell –Hypotonic:a solution has a lower solute concentration than the inside of a cell

19. 4.2 Permeability of the Plasma Membrane Osmosis –Isotonic:the solute concentration is equal inside and outside of a cell –Hypotonic:a solution has a lower solute concentration than the inside of a cell –Hypertonic:a solution has a higher solute concentration than the inside of a cell

20. Osmosis in Animal and Plant Cells

21. 4.2 Permeability of the Plasma Membrane Transport by Carrier Proteins –Carrier proteins combine with a molecule or ion to be transported across the membrane.

22. 4.2 Permeability of the Plasma Membrane Transport by Carrier Proteins –Carrier proteins combine with a molecule or ion to be transported across the membrane. –Carrier proteins are required for: Facilitated Transport

23. 4.2 Permeability of the Plasma Membrane Transport by Carrier Proteins –Carrier proteins combine with a molecule or ion to be transported across the membrane. –Carrier proteins are required for: Facilitated Transport Active Transport

24. Facilitated Transport Small molecules that are not lipid-soluble Molecules combine with carrier proteins Molecules follow the concentration gradient Energy is not required

25. 4.2 Permeability of the Plasma Membrane Active Transport –Small molecules –Molecules combine with carrier proteins –Molecules move against the concentration gradient –Energy is required

26. The Sodium-Potassium Pump

27. 4.2 Permeability of the Plasma Membrane Vesicle Formation –Transport of large molecules –Requires energy –Keeps the macromolecule contained

28. 4.2 Permeability of the Plasma Membrane Vesicle Formation –Exocytosis - Vesicles form as a way to transport molecules out of a cell

29. Exocytosis

30. Vesicle Formation –Endocytosis - Vesicles form as a way to transport molecules into a cell

31. Vesicle Formation –Endocytosis - Vesicles form as a way to transport molecules into a cell Phagocytosis: Large,particulate matter

32. Vesicle Formation –Endocytosis - Vesicles form as a way to transport molecules into a cell Phagocytosis: Large,particulate matter Pinocytosis: Liquids and small particles dissolved in liquid

33. Vesicle Formation –Endocytosis - Vesicles form as a way to transport molecules into a cell Phagocytosis: Large,particulate matter Pinocytosis: Liquids and small particles dissolved in liquid Receptor Mediated Endocytosis: A type of pinocytosis that involves a coated pit

34. Three Methods of Endocytosis