1. Introduction to the Method of Bone-Subtraction and Our Proposal Advisor : Ku-Yaw Chang Student : Wei-Lu Lin( 林威如 ) 2015/3/11

2. Outline  Introduction  Bone-Subtraction  Algorithm  Conclusion 2015/3/11 2

3. Introduction  CT and CTA Image 2015/3/11 3 CTA Image(Contrast Image) CT Image(Mask Image)

4. Introduction  General Segmentation 2015/3/11 4

5. Introduction  General Segmentation 2015/3/11 How to Solve ? 5

6. Bone-Subtraction  Contrast and Mask Image(Data)  Based on Matched Mask Bone Elimination(MMBE)  Registration Operation  Post-processing 2015/3/11 Contrast Image(CTA) Mask Image(CT) 6

7. Bone-Subtraction 2015/3/11  Example Volume Rendering[1] Surface Rendering 7

8. Bone-Subtraction 2015/3/11  Example Cervical Arteries [2] Legs Arteries [2] 8

9. Bone-Subtraction  A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE  Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE 2015/3/11 9

10. A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE  Steps  Pre-processing  3D Rigid Registration Based on Mutual Information  Bone Mask Extraction 2015/3/11 10

11.  Step1: Pre-processing  Remove Non-interesting Region  Mapping 2015/3/11 CTA ImageCT Image 11 A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE

12.  Step2 : 3D Rigid Registration  3D Rigid Registration  Translation  Rotation  Mutual Information  Similarity Measure 2015/3/11 12 A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE

13.  Step3 : Bone Mask Extraction  Thresholding  Refine Bone Mask 2015/3/11 13 A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE

14.  Result 2015/3/11 14 A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE

15. Bone-Subtraction  A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE  Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE 2015/3/11 15

16. Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE  Steps:  Watershed Algorithm on CT Image  Register Individually 2015/3/11 16

17.  Step1: Watershed Algorithm on CT Image 2015/3/11 CT ImageCTA Image 17 Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE

18.  Step2: Register Individually 2015/3/11 18 Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE

19.  Result 2015/3/11 19 Removal of Bone in CT Angiography of the Cervical Arteries by Piecewise MMBE

20. Algorithm Start Bone Subtraction Labeling Thresholding End 2015/3/11 20

21. Algorithm Start Bone Subtraction Labeling Thresholding End 2015/3/11 21

22. Algorithm  Volume Image  Contrast  Mask  Binary Image  B1  B2 Contrast ImageMask Image B1B2 2015/3/11 22

23. Algorithm  Thresholding  Original Value: 130 Thresholding Bone Subtraction Labeling 2015/3/11 23

24. Algorithm Start Bone Subtraction Labeling Thresholding End 2015/3/11 24

25. Algorithm  Registration  Region  B1 and B2 as Fixed and Moving Thresholding Bone Subtraction Labeling 2015/3/11 Fixed Image(B1)Moving Image(B2) After Registrtion -Moving Image(B2) Transform Parameter 25

26. Algorithm  Bone Filter  Use B2 Position to Search Around In Contrast Image  Filter Limit  Radius = 10  Use Original Value > 350 to Remove in B1 Thresholding Bone Subtraction Labeling B1After Registrtion -Moving Image(B2) Contrast ImageMask Image 1 2 2015/3/11 26

27. Algorithm  Bone Filter  Use B2 Position to Search Around In Contrast Image  Filter Limit  Radius = 10  Use Original Value > 350 to Remove in B1 Thresholding Bone Subtraction Labeling After Registrtion -Moving Image(B2) Fixed Image(B1) Contrast ImageMask Image 1 2 2015/3/11 27

28. Algorithm  Erosion  For B1  Remove Boundary  Not to Do Dilation  Reserve Vessel Structure Thresholding Bone Subtraction Labeling 2015/3/11 Fixed Image(B1) Contrast ImageMask Image 1 2 After Registrtion -Moving Image (B2) 3 28

29. Algorithm Start Bone Subtraction Labeling Thresholding End 2015/3/11 29

30. Algorithm  Labeling  Recovery the Vessel  Reference  Contrast Image and B2 Thresholding Bone Subtraction Labeling B2B1 Mask Image Contrast Image 2015/3/11 30

31. Algorithm  Labeling  Recovery the Vessel  Reference  Contrast Image and B2 Thresholding Bone Subtraction Labeling B2 B1 Contrast Image Mask Image 2015/3/11 31

32. Conclusion  Condition  Registration 2015/3/11 32 Contrast Image Mask Image

33. Conclusion  Condition  Registration 2015/3/11 33 Rotation

34. Conclusion  Condition  Labeling 2015/3/11 34

35. Conclusion  Difference  Matched Mask Bone Elimination(MMBE)  Flexibility 2015/3/11 35

36. Reference  [1] DSCT.com http://www.dsct.com/index.php/article-series-dual- energy-ct-scientific-evidence-and-clinical-application- 27-head-and-neck/  [2] TOSHIBA MEDICAL SYSTEM EUROPE http://www.toshiba-medical.eu/eu/product- solutions/computed-tomography/aquilion-one-vision- edition-overview/aquilion-one-vision-edition-advanced- applications/ 2015/3/11 36

37. Reference  [3] Fangfang Han, Jinzhu Yang, Dazhe Zhao and Hong Zhao, “A Fast Subtraction Algorithm of Brain CT Angiography Image Based on MMBE,” International Conference on Information and Automation (ICIA), 2012, pp. 226-229  [4] M. van Straten, H.W. Venema, G.J. Streekstra, C.B.L.M. Majoie, G.J. den Heeten and C.A. Grimbergen, “Removal of bone in CT angiography of the cervical arteries by piecewise matched mask bone elimination,” Proceeding of the IEEE International Conference on Information and Automation Shenyang, China, June 2012 2015/3/11 37

38. The End Thank you for listening 2015/3/11 38