1. Life Sciences Trend Analysis 2013 FRANCE

2. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com www.biotechgate.com The French Biotech Database is a part of the global Biotechgate and is brought to you in partnership with APIM - the Lille Métropole Development Agency; assisting companies to establish and grow thier Business in France from Lille. www.frenchbiotech.com Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.comwww.venturevaluation.com

3. Status of the Sector 2012 Statistics France 2013 Statistics 392Total Biotech Companies685 91Biotech - Therapeutics159 242Biotech - R&D Services349 59Biotech - Other177 96%Percentage of SME's94% 6%Percentage of Publicly Owned Companies4% USD 24 M (2011)Financing/Capital Raised USD 150 M (2012) 204Licensing Opportunities342

4. Key Activities of Biotechnology Companies Historical Data Subsector20132012 Environment 4%1% Contract Research and Manufacturing 15%19% Diagnostics and Analytical Services 17%18% Genomics and Proteomics 5%7% Food and Nutraceuticals 4%3% Other Services and Suppliers 26%25% Therapeutics 13% Other16%14%

5. Company Foundation Timeline

6. Company Ownership Historical Data Subsector 2013 2012 Private/ Independent 84%87% Public 4%6% Subsidiary12%7%

7. Sources of Company Foundations Historical Data Company Foundation 2013 2012 Independent foundation 57% 70% Spin-off from company 2% 3% Spin-off from public institution / NPO 4% 9% Spin-off from university 3% Subsidiary 11% 10% Other4%

8. Number of Employees Historical Data No. of Employees 2013 2012 1-10 32% 26% 11-50 49% 56% 51-200 15% 14% Greater than 2004% 6%

9. Products in the Pipeline

10. Financing Rounds in France & 3 Major Financing Rounds Financing for 2012/2013 Private Biotech Companies Major Financings in 2012/2013SectorUSD M Magnisense SARL Biotech – R&D 59 Poxel SA Biotech – Therapeutics & Diagnostics 17 TxCell Biotech – Therapeutics & Diagnostics 16

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12. Terms of Use The “French Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof. The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions. Biotechgate c/o Venture Valuation VV AG Kasernenstrasse 11+41 (43) 321 86 60 8004 Zurichinfo@venturevaluation.com Switzerlandwww.venturevaluation.com