1. Study Flow Diagram Holvoet P, et al. JAMA 2008;299:2287-93 The Figure shows the selection of 1889 participants who did not have metabolic syndrome at year 15 (2000-2001) for whom fresh frozen blood samples were available at year 15 for measuring plasma oxidized low-density lipoprotein and for whom all data were available at years 15 and 20 (2005-2006). aParticipants could be excluded for more than 1 reason.

2. Cross-sectional Associations Between Year 15 Oxidized Low-Density Lipoprotein and Demographic, Health Behaviors, and Clinical Variables (N = 1889 Without Metabolic Syndrome at Year 15) a Holvoet P, et al. JAMA 2008;299:2287-93

3. Cross-sectional Associations Between Year 15 Low-Density Lipoprotein Cholesterol and Demographic, Health Behaviors, and Clinical Variables (N = 1889 Without Metabolic Syndrome at Year 15) a Holvoet P, et al. JAMA 2008;299:2287-93

4. Incidence of Year 20 Metabolic Syndrome by Year 15 Oxidized Low-Density Lipoprotein or Low-Density Lipoprotein Cholesterol Concentrations (N = 1889 Without Metabolic Syndrome at Year 15) a

5. Holvoet P, et al. JAMA 2008;299:2287-93 Incidence of Each Component of the Metabolic Syndrome at Year 20 by Year 15 Oxidized LDL Concentrations or LDL Concentrations ( (N = 1889 Without Metabolic Syndrome at Year 15) a