1. Appendix 1 Jeong et al. A. mPPAR  0 6 12 18 (-)WYRosiGW CG269 1  M 1  M 1  M Relative reporter activity * ** B. hPPAR  0 5 10 15 20 (-)WYRosiGW CG269 1  M 1  M 1  M Relative reporter activity ** * * 0 2 4 6 8 (-)WYRosiGWCG269 Relative reporter activity PPAR  C. # D. LXR Relative reporter activity 0 2 4 6 8 10 (-)T1317WYRosiGWCG269 # E. Relative reporter activity EC 50 = 39 nM PPAR  0 0.0010.010.11 10 (  M) 0 5 10 15 // F. PPAR  EC 50 =2.69  M Relative reporter activity (  M) 00.0010.010.1110 0 5 15 //

2. Appendix 2 Jeong et al. A. B.

3. Jeong et al. Appendix 3 * * * * B. PPAR  WY GW Rosi Trypsin + + + + ++++++ CG269 ++++ + * * A. * * Trypsin PPAR  WY GW Rosi + + + + ++++++ CG269 ++++ +

4. Jeong et al. Appendix 4 Fold of  -oxidation 0 0.5 1.0 1.5 (-)WYRosiCG269 * * 0 2 4 6 8 ACOCPT1 Relative gene expression # * # * * * * * * A. B.

5. Jeong et al. Appdneix 5 A. 0 2 4 6 8 aP2Acrp30LPLCD36 Relative gene expression 3T3-L1 # * * * * * * * * # # # # * * B. 0 2 4 6 8 aP2Acrp30LPLCD36 3T3-F442A Relative gene expression # # * * # # * * * * # # # * * Relative mRNA PPAR  (-)Rosi CG269 (-)Rosi CG269 (-)Rosi CG269 0.0 0.5 1.0 1.5 * * # * * * * * * *# * # * * ¶ ¶ ¶ ¶ ¶ ¶ aP2CD36 Acrp30 D. C.C. 0 1 2 3 4 aP2Acrp30LPL Relative gene expression WAT # * # # # * Veh WY Rosi CG269

6. Jeong et al. Appendix 6 A. B. 118 6 15 39 1 Total 246 Rosi 218 CG269 170 8578 Upregulation Downregulation 100 91 79 C. CxCl12 Retn PmvK Mthfd1l Iars Agpat3 Cfd Hadhb Ifi30 Veh CG269 CG269 Rosi 0.5  M 5  M 1  M 1 2 3 4 5 6 7 8

7. 0 2 4 6 8 10 TNF  IL-1  IL-6iNOSMCP1COX2MMP9 Relative gene expression 3T3-F442A * * * * * ** * # # # # # ¶ ¶ ¶ ¶ ¶ # ¶ ¶ ¶ ¶ ¶ ¶ ¶ # ¶ ¶ ¶ ¶¶ ¶ ¶ Jeong et al. Appendix 7

8. Jeong et al. Average daily food intake (g) 0.0 2.5 5.0 7.5 VehWYRosiCG269 Appendix 8

9. Jeong et al. Appendix 9 Relative gene expression * * * # * * *

10. Jeong et al. Appendix 10 VehWYRosiCG269