1. Herpes Virus

2. Herpes Virus
herpesviridae
8 types

3. Human herpes type
Name 1
Herpes simplex-1 (HSV-1) 2
Herpes simplex-2 (HSV-2) 3
Varicella Zoster virus (VZV) 4
Epstein-Barr Virus (EBV) 5
Cytomegalovirus (CMV) 6
Human herpes virus-6 (HHV-6) 7
Human herpes virus-7 (HHV-7) 8
Human herpes virus-8 (HHV-8)

4. common properties shape and structure spherical, 120-200nm core capsid
tegument
envelope

6. common properties replication immediate-early proteins early proteins
late proteins

7. common properties types of infection apparent infection
latent infection
integration infection
congenital infection

8. Herpes simplex virus

9. Biological Propeties
shape and structure

10. Biological Propeties
Typing
HSV-1
HSV-2

11. Biological Propeties
Cultivation

12. Pathogenesis Source: human transmission HSV-1: contact
HSV-2: sex contact; vertical transmission

13. Pathogenesis types of infection Primary infection
Latent infection and reactivation

14. Primary infection HSV-1 HSV-2 6m-2y herpes gingivostomatitis
Herpes keratitis
Eczema herpeticum
HSV Encephalitis
HSV-2
Adults: Genital herpes
Neonates: HSV infection of neonates

17. Latent infection and reactivation
HSV
→ primary infection
→ a little amount of virus remained
→ HSV-1: 三叉神经节, 颈上神经节
HSV-2:骶神经节
→ latent infection
→ reactivated by several stimulators
→ arrive at the mucosa that was initially infected

18. Varicella-Zoster Virus

19. Varicella-Zoster Virus
source: human
Transmission
respiratory aerosols
direct contact with skin lesions

20. Disease VZV → viremia → chicken pox → 脊髓后根神经节; 脑神经的感觉神经节
→ reactivation
→ shingles

21. Epstein-Barr Virus

22. Epstein-Barr Virus Burkitt‘s lymphoma nasal pharyngeal carcinoma
infectious mononucleosis

23. Epstein-Barr Virus
source: human
transmission
saliva
sex contact

24. Epstein-Barr Virus types of infection
multiplication infection: epithelial cells
latent infection: B lymphocytes
transformation

25. Epstein-Barr Virus Diseases Infectious mononucleosis
Burkitt's lymphoma
Nasopharyngeal cancer

27. Human Cytomegalovirus (HCMV)

28. HCMV source: human Transmission maternal-infant transmission
close contact
sexually transmitted
blood transfusions and transplants

29. Disease Congenital infection Perinatal infection
placenta
Cytomegalic inclusion disease
Perinatal infection
adolescent and adult infection
Granular fever
Disease in immunosuppressed patients
transformation and carcinogenesis

30. Human herpes virus 6

31. Human herpes virus 6 latent infection in T cells
Children: exanthem subitum
Adults: mononucleosis

32. Virus
Treatment
Vaccination
HSV
ACV (acyclovir) No
VZV
ACV
Live attenuated vaccine virus
EBV
being developed
HCMV
GCV (Ganciclovir