1. The world leader in serving science Antaris EX Process Analyzer Antaris Product Launch 2006

2. 2 Antaris EX Product Positioning  Positioning Statement Antaris EX is the near infrared fiber optic process analyzer that provides the most complete and use-ready process monitoring and control solution, through the use of revolutionary sampling technology, ready-for-environment configurations, and integrated control and communications systems in a single package sourced and supported by a single supplier.

3. 3 Antaris EX: A complete process analyzer  Hazardous environments  Integrated computing  Integrated process communications  Same sampling technology and advantages as MX Simultaneous measurements with internal referencing and qualification  Not a box that you have to put inside of another box!  Complete new lineup of probes  There is no match for this product on the market

4. 4 Example environments  Production environments that have occasional (Z1)or constant (Z2) presence of explosive vapors Pharmaceutical dryers are CID1 for example  Messy areas that need wash down analyzers  Outdoor applications  Non hazardous applications where an integrated solution us best – local PC, local I/O  Cases where the it is easiest for the customer to source an integrated, complete package is most complete

5. 5 Example Applications  Batch reaction monitoring and control  Continuous process monitoring  Drying moisture and endpoint  Fermentation monitoring

6. 6 Spectrometer Technology  ParaLux illumination and MX footprint  No covers on the analyzer internally  Explosion proof purge flow requires continuous purge volume (putting a box in a box as-is is not acceptable)

7. 7 Taking a system into real process applications

8. 8 Hazardous environments  Three EX models: EX-Z1 for Class I Division 1/Zone 1 Environments EX-Z2 for Class I Division 2/Zone 2 Environments EX-IP65 for  Enclosures are: Stainless steel and corrosion proof Individually certified  Vortex cooling provides operating temperature range of -20 to 40 C  Purge systems (different for each environment) linked to power of system  On Z1 unit, all wiring runs through explosion proof box

9. 9 Hazardous Environments Overview  Class I Division 1/Zone 1: High chance/frequent presence of combustible atmosphere Requires continuous positive pressure  Class I Division 2/Zone 2: Occasional/infrequent presence of combustible atmosphere  Certifications: ATEX, NEC, CSA, and IECEX

10. 10 IP (Ingress Protection) and NEMA  Non Explosion-Proof Antaris EX: IP 65  System is not NEMA 4X – which is IP66 (NEMA 4) + extreme corrosion resistance (the X)  Most claims of NEMA 4X really are IP65; testing is severe – for example EXPO cannot provide a NEMA4X enclosure

11. 11 Purge Control  Maintains positive pressure differential  Loss of pressure differential cuts power to the system  Does not allow power to the system until  Purely pneumatically controlled - Failsafe

12. 12 Cooling  Vortex cooling (requires compressed air source)  Used to keep instrument in optimum operating temperature range – sealed box heats up  Air conditioning option available if no air source available  Testing in Wisconsin hits the other extreme:

13. 13 Mounting  Stand mount (tip proof) Purge lines for hazardous environments may be hard- plumbed, so system would not be moved  Wall mount  Door opening moved to front, serviceable from the front

14. 14 Computing  Can be integrated or external  Integrated computing must be purchased from us with the system Keyboard configured for environment rating  Internal I/O Controller connection  Ethernet/Network Connection

15. 15 External computing  EX Remote Computer Option Part Number ~ Includes EX blank door and USB extender ~ Extends 50 Meters over CAT-5 wiring Does not include the computer

16. 16 Example: Equipment Location Scenarios

17. 17 Antaris EX (and MX) Process Communications  OPC (RESULT and ethernet)  4-20 mA (RESULT and hardware option)  Digital relay (RESULT and hardware option)  Allows communication to and from control systems and equipment

18. 18 OPC Server for industrial integration  What is OPC? OLE for Process Control. It is the new industry standard communication protocol for PLC, DCS, MES manufacturing and control systems and devices.  OPC is a client server protocols that works over standard networks.  OPC is an extremely powerful tool that allows: Output to process control systems Data into databases Connection to alarm systems Connection to valve control systems such as PLC controllers

19. 19 OPC Server RESULT OPC Server DCS MES PLC Antaris PC Simple Ethernet, no hardware or special wiring necessary

20. 20 The Antaris EX Process Communications Controller Integrated or panel mount version available (Panel mount also available for all other Antaris systems) Based on OPTO-22 SNAP system with Plug- in I/O Modules

21. 21 Process Communications.  PLC Option, includes: For use inside EX enclosure Opto22 Ultimate Brain PLC two standard I/O Modules providing 4 channels of Digital Input and 4 channels Digital Output space for at least 8 additional I/O Modules NOTE: only four I/O lines on EX-Z1/D1 systems  Antaris PLC 4 Channel 4-20 mA Output Kit  Antaris PLC 4 channel 4-20 mA I/O Kit  Antaris PLC 8 Channel 4-20 mA Output Kit  Antaris PLC 8 ch 4-20 mA I/O 4 Dig I/O Ch Kit

22. 22 RESULT I/O: Industrial Automation Options Operate at a higher level than read I/O report I/O Workflow events Dedicates line to super-level communications outside the workflow Analyzer health Start Stop Etc

23. 23 RESULT Multi-Channel and Trend Display  Measurement data (not spectra) stored in database  Display shared between multi- channel and multi-component  Can be set and adjusted in the Operation display window (settings outside of workflow control)  Can review historical trend data while process data collects in background

24. 24 Control Strategy Examples – Batch Reactor

25. 25 Control Strategy Examples – Fluid bed dryer Moisture concentration and temperature fed directly to readouts or DCS DCS/SCADA Fiber optic probe data acquisition; probe purge control Control of drying process Fluid bed dryer photo courtesy of ServoLift

26. 26 Fiber Optic: Choosing the Correct Probe Sample Opacity Transmission sampling optimal Reflection sampling optimal Performance

27. 27 Fiber Optic Considerations  Fiber response varies with length and wavelength  Above 5300 cm -1 most lengths of fiber are minimally absorbing (<0.5 Abs)  Below 7000 cm -1 has good sample information  Bundles needed for diffuse reflection  Bundles better but more expensive for longer distances Length Abs (4762 cm -1 ) 78m1.2 46m0.8 38m0.7 25m0.7 14m0.4

28. 28 Fiber Optic Influence on Analyses  Fiber content, length, positioning are all sources of variability that can affect measurement  Considerations for calibration transfer, may have to be compensated in final online implementation  ACLS Software and the new RESULT Spectral Corrections can be used for compensate for fiber differences  New spectral corrections

29. 29 ACLS Corrects for Fiber Optic Differences Without Altering the Original Calibration PLS ACLS

30. 30 Antaris EX Unique Value Proposition – bird’s eye view  Simultaneous multiplexing  Internal backgrounds and qualification  Hazardous environment ready and certified  Integrated computing  Integrated process communications  Package-able with differentiated specialty probe packages for true application systems  Common software, validation, and data with all other Antaris products  See Antaris EX Lockout specifications in sales binder

31. 31 Antaris EX Status  Antaris EX Class 1 Div 1 unit installed at AstraZeneca / Wilmington Has retractable dryer probe  North American pipeline has several EX projects Sun Chemical – Ohio and PA Cephalon – Utah Various Biofuels  Europe pipeline has various EX projects BP solar Novo Nordisk Siemens