1. Malaria pan-R Malaria cassette

2. Agenda Disease overview Infectious agents Diagnosis pan-R Malaria cassette: specifications Conclusion

3. Malaria Overview One of the most common & serious tropical diseases –300-500 million clinical cases worldwide –1-2 million deaths –41% of the world's population live in areas where malaria is transmitted –rising each year as drug resistance increases and health systems deteriorate Transmitted via the female Anopheles mosquito No vaccine

4. Global distribution

5. Infectious agents Caused by 4 species of protozoal parasites from the Plasmodium genus –Plasmodium falciparum –Plasmodium vivax –Plasmodium ovale –Plasmodium malariae P. falciparum causes the most severe form of the disease If P. falciparum infection is not treated or the parasites are resistant to the drug-therapy, the disease can become life-threatening

6. Infectious agents P.falciparum infection is most prevalent throughout Africa Increasing P.falciparum infections throughout Latin America, the Western Pacific and the Asia-Pacific regions Rapidly developing resistance to many of the drugs commonly used to treat malarial infections Expensive drug combination therapies now needed Accurate and rapid diagnosis of infection is more crucial than ever

7. Diagnosis Accurate, Rapid & Confident diagnosis of infection is crucial to providing effective treatment to manage the disease Misdiagnosis  improper & unnecessary treatment –Increased therapy costs –Increased risk of drug resistance

8. Diagnosis Accurate, Rapid & Confident diagnosis: –Appropriate & effective drug treatment –Greater control over spread of infection Great advantage for health workers to be able to differentiate a P. falciparum malarial infection Increasing importance on the accurate diagnosis of parasitaemia prior to treatment P. falciparum drug resistance –expensive multi-drug regimes

9. Diagnosis The pan-R Malaria Cassette can: –Detect all pathogenic malaria antigens, in whole blood –Differentiate a P.falciparum infection Provides qualitative detection of: –Plasmodium falciparum –Plasmodium vivax –Plasmodium ovale –Plasmodium malariae

10. Diagnosis Provides patients and health-workers with a useful diagnosis –Rapid implementation of therapy –Correct therapy –Prioritise precious (& expensive) resources –Save lives

11. Specifications Name: pan-R Malaria Cassette Cat. No. R-MAL01D Expiry: 18 months Storage: 4 – 28°C (room temperature, below 30°C) Antigen:HRP2, P. aldolase Sample:Whole blood Test time:15 minutes Kit size:25 tests & Collection devices, 1 bottle of buffer Procedure:2 well cassette, 5uL serum, 5 drops of buffer

12. Procedure

13. Interpretation

14. Performance Characteristics Table 1: Sensitivity and Specificity of the Panbio pan-R Malaria Cassette P. falciparum versus non-P. falciparum Characterised Specimens Specimen characterisation (Microscopy & PCR) Panbio pan-R Malaria Cassette PositiveNegativeTotal P.falciparum26211273 Non P.falciparum32335 Negative1316317 Total295330625

15. Performance Characteristics 95% CI* Serological Sensitivity (P. falciparum) =262/27396.0%92.9-98.0% Serological Sensitivity (non-P. falciparum) =32/3591.4%76.9-98.2% Serological Specificity (Negative) =316/31799.7%98.3-100.0% Relative Serological Agreement =610/62597.6%96.1-98.7% *Confidence Interval

16. pan-R Malaria Cassette Product brochure Summary Card

17. Competitors DiaMed OptiMAL Binax NOW Standard Diagnostics Core Diagnostics

20. Binax NOW OptiMAL

21. Panbio

22. Conclusion

23. www.panbio.com