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 THEY ARE SUGAR CONTAINING LIPIDS.  THEY ARE DERIVED FROM SPHINGOLIPDS.  THEY DO NOT CONTAIN PHOSPHATE.  GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR.

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Presentation on theme: " THEY ARE SUGAR CONTAINING LIPIDS.  THEY ARE DERIVED FROM SPHINGOLIPDS.  THEY DO NOT CONTAIN PHOSPHATE.  GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR."— Presentation transcript:

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2  THEY ARE SUGAR CONTAINING LIPIDS.  THEY ARE DERIVED FROM SPHINGOLIPDS.  THEY DO NOT CONTAIN PHOSPHATE.  GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR BODY,PARTICULARLY IN NERVOUS TISSUE SUCH AS BRAIN

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4 CEREBROSIDES SULFATIDES GLOBOSIDES GANGLIOSIDES

5  IT IS THE SIMPLEST GLYCOLIPID  IT IS FOUND IN HIGH CONCENTRATION IN NERVE TISSUE MEMBRANE. Eg.GALACTOCEREBROSIDE

6  THEY ARE CEREBROSIDE IN WHICH THE MONOSACCHARIDE CONTAINS A SULFATE ESTER Eg. SULFOGALACTOCERAMIDE

7  THEY ARE IMPORTANT CONSTITUENT OF RBC MEMBRANE AND DETERMINANTS OF ABO BLOOD GROUP SYSTEM.

8  THEY ARE INVOLVED IN CELL MEMBRANE RECEPTORS FOR CERTAIN POLYPEPTIDE HORMONES.

9  THEY ARE IMPORTANT IN CELL ADHESION RECOGNITION.  AS RECEPTORS FOR BACTERIAL TOXINS (Eg. THE TOXIN THAT COLERA).  ABO BLOOD GROUP SUBSTANCES.  IMPORTANT CONSTITUENTS OF THE NERVOUS TISSUE SUCH AS BRAIN.

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11 ON CELL MEMEBRANE OF RED BLOOD CELL OLIGOSACCRIDES THAT DETERMINE THE SPECIFC NATUER OF THE ABO SUBSTANCES APPEAR TOBE PRESENT IN GLYCOSPHINGOLIPIDS

12 SPHINGOSINE CERAMIDE GLUCOCRERBROCYTE GALACTOCEREBROSIDE UDP-GLUCOSE UDP UDP-GALACTOSE UDP GANGLIOSIDE GLOBOSIDE SULFATIDES UDP-SUGARS CMP-NANA PAPS UDP-SUGARS

13  FORMED FROM CERAMITE.  THE AMINO GROUP OF SPHINGOSINE BACK BONE IS ACYLATED BY A C FATTYACID OCCUR IN MANY GLYCOSPHINGOLIPIDS,CEREBROSIDE,SULFATEIDES,GLBOSIDES,GANGLOSIDES,ARE THE DIFFERENT TYPES OF GLYCOLIPIDS.  IN A CEREBROSIDE GLUCOSE OR GALACTOSE IS LINKED TO THE TERMINAL GROUP OF CERAMIDE TO FORMGLUCOCEREBROSIDE. 24

14  CERAMIDE REACTS WITH UDP-GLUCOSE TO FORM GLUCOCERBROSIDE.  GLALCTOCEREBROSIDE REACTS WITHACTIVE SULPHATE 3’- PHOSPHOADENOSINE 5’-PHOSPHOSULFATE TO FORM SULFATIDES.ADDITIONAL SUGARS MAY BE ADDED TO CERAMITES TO FORM GLOBOSIDES

15  GAUCHER’S DISESSE  TAY-SACHS DISEASE THEY ARE DUE TO GENETIC DEFECT IN THE PATHWAY OF GLYCOLIPID DEGRADATION IN THE LYSOSOMES

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