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Published byTobias Nichols Modified over 8 years ago
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THEY ARE SUGAR CONTAINING LIPIDS. THEY ARE DERIVED FROM SPHINGOLIPDS. THEY DO NOT CONTAIN PHOSPHATE. GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR BODY,PARTICULARLY IN NERVOUS TISSUE SUCH AS BRAIN
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CEREBROSIDES SULFATIDES GLOBOSIDES GANGLIOSIDES
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IT IS THE SIMPLEST GLYCOLIPID IT IS FOUND IN HIGH CONCENTRATION IN NERVE TISSUE MEMBRANE. Eg.GALACTOCEREBROSIDE
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THEY ARE CEREBROSIDE IN WHICH THE MONOSACCHARIDE CONTAINS A SULFATE ESTER Eg. SULFOGALACTOCERAMIDE
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THEY ARE IMPORTANT CONSTITUENT OF RBC MEMBRANE AND DETERMINANTS OF ABO BLOOD GROUP SYSTEM.
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THEY ARE INVOLVED IN CELL MEMBRANE RECEPTORS FOR CERTAIN POLYPEPTIDE HORMONES.
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THEY ARE IMPORTANT IN CELL ADHESION RECOGNITION. AS RECEPTORS FOR BACTERIAL TOXINS (Eg. THE TOXIN THAT COLERA). ABO BLOOD GROUP SUBSTANCES. IMPORTANT CONSTITUENTS OF THE NERVOUS TISSUE SUCH AS BRAIN.
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ON CELL MEMEBRANE OF RED BLOOD CELL OLIGOSACCRIDES THAT DETERMINE THE SPECIFC NATUER OF THE ABO SUBSTANCES APPEAR TOBE PRESENT IN GLYCOSPHINGOLIPIDS
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SPHINGOSINE CERAMIDE GLUCOCRERBROCYTE GALACTOCEREBROSIDE UDP-GLUCOSE UDP UDP-GALACTOSE UDP GANGLIOSIDE GLOBOSIDE SULFATIDES UDP-SUGARS CMP-NANA PAPS UDP-SUGARS
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FORMED FROM CERAMITE. THE AMINO GROUP OF SPHINGOSINE BACK BONE IS ACYLATED BY A C FATTYACID OCCUR IN MANY GLYCOSPHINGOLIPIDS,CEREBROSIDE,SULFATEIDES,GLBOSIDES,GANGLOSIDES,ARE THE DIFFERENT TYPES OF GLYCOLIPIDS. IN A CEREBROSIDE GLUCOSE OR GALACTOSE IS LINKED TO THE TERMINAL GROUP OF CERAMIDE TO FORMGLUCOCEREBROSIDE. 24
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CERAMIDE REACTS WITH UDP-GLUCOSE TO FORM GLUCOCERBROSIDE. GLALCTOCEREBROSIDE REACTS WITHACTIVE SULPHATE 3’- PHOSPHOADENOSINE 5’-PHOSPHOSULFATE TO FORM SULFATIDES.ADDITIONAL SUGARS MAY BE ADDED TO CERAMITES TO FORM GLOBOSIDES
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GAUCHER’S DISESSE TAY-SACHS DISEASE THEY ARE DUE TO GENETIC DEFECT IN THE PATHWAY OF GLYCOLIPID DEGRADATION IN THE LYSOSOMES
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