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Blood Volume and Oxygenation Changes in the Forearm Muscles of Stroke Patients Measured Using Non- Invasive Surface Near-Infrared Spectroscopy PI: Mahsa.

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Presentation on theme: "Blood Volume and Oxygenation Changes in the Forearm Muscles of Stroke Patients Measured Using Non- Invasive Surface Near-Infrared Spectroscopy PI: Mahsa."— Presentation transcript:

1 Blood Volume and Oxygenation Changes in the Forearm Muscles of Stroke Patients Measured Using Non- Invasive Surface Near-Infrared Spectroscopy PI: Mahsa Ranji Presenter: Jeffrey Sugar

2 Principles of The Method Wavelength (nm) Ε (molar extinction Coefficient) Beer-Lambert Law: I(t,λ) I0(λ)I0(λ) LiLi Using Several Wavelengths of light we can model the unknown concentrations as a Linear Regression Model  Optical path length is related to the source- detector distance:

3 Instrumentation Hemi paretic Stroke Survivors Have There Blood Oxygenation Levels analyzed as they perform a light digital workout The Results Have shown that The oxygenation levels are significantly affected on the paretic side of the patient. This effect is not observed in Control subjects

4 Cytochrome C Oxidase Cytochrome C Oxidase Is an Important Enzyme in the Metabolic Cycle. Analyzing this chemical will allow for analysis of metabolic activity during neurological disturbances. Ex-vivo studies have been performed to extract the ratio of reduced vs oxidized cytochrome c oxidase while in the presence of Blood


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