1. -7 -6 -5 -4 -3 -2 0 03691215182124 Treatment month Adjusted mean change in IPSS from baseline (ITT, LOCF) Tamsulosin -4.8 -4.5 -4.4 -4.3 -4.5 -4.4 -4.7 -4.5 Dutasteride -2.8 -3.4 -4.0 -4.2 -4.8 -4.9 -5.0 -4.9 Combination -4.8 -5.4 -5.6 -6.0 -6.2 Adapted from Roehrborn et al. J Urol 2008;179:616-21. CombAT Primary End Point Mean Change in IPSS from Baseline

2. 0.0 0.5 1.0 1.5 2.0 2.5 3.0 06121824 Treatment month Adjusted mean change in Q max (mL/sec) from baseline (ITT, LOCF) P<0.001 combo vs. tamsulosin P<0.006 combo vs. dutasteride 1.2 0.9 1.1 0.9 TamsulosinDutasteride 1.5 1.8 1.9 1.2 Combination 2.0 2.3 2.4 Adapted from Roehrborn et al. J Urol 2008;179:616-21. CombAT - Secondary End Point: Mean Change in Q max from Baseline

3. Adapted from Barkin et al. BJU Int 2009 Feb 23 [Epub ahead of print]. CombAT Change in BII Score at Two Years

4. Adapted from Barkin et al. BJU Int 2009 Feb 23 [Epub ahead of print]. CombAT Change in IPSS Q8 Score at Two Years