1. Outcome of 129 children after antenatal exposure to cancer treatment: Results of a case-control study from the International Network on Cancer, Infertility and Pregnancy registry Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands

2. 129 study children born to mothers with cancer during pregnancy 129 control children born after an uncomplicated pregnancy and delivery 89 chemotherapy (+ surgery) 4 radiotherapy (+ surgery) 7 chemotherapy + radiotherapy (+ surgery) 1 trastuzumab 1 interferon-β 13 surgery only 14 no treatment during pregnancy 96 chemotherapy 11 radiotherapy 1:1 matched Study design

3. Methods General HealthCognitive outcomeHeart morphology and functions General pediatric and clinical neurological examination Bayley Scales of Infant Development – second / third edition Echocardiography General health questionnaireElectrocardiography

4. Perinatal outcome Median GA: 36 weeks (range 27-41) Prematurity 8,5% very preterm (27,0-31,9w) 12,4% moderate preterm (32,0-33,9w) 40,3% late preterm (34,0-36,9w) 38,8% full term (37,0-41,9w) Median birth weight: 2705g (range 720-4690) vs. 2755g (1100-4905) in controls (P=0,502) 61,2% born preterm

5. Postnatal growth MalesFemales Study group Control group Weight (kg) Head circumference (cm) Length (cm)

6. General health Incidence of medical problems Need for surgery or medical care  comparable between study and control group

7. Study group Control group Cognitive outcome ------

8. Cognitive outcome and chemo cycles

9. X ---- Study group Control group Cognitive outcome and prematurity

12. Acknowledgements Fund for Cancer in Pregnancy