1. Exovene: Treatment of Testicular Cancer Chylee Martin and Helaina Lefler

2. Population Young adult males between the ages of 18 and 40 who have been diagnosed with testicular cancer

3. Potential Risks and Benefits Risks Hair loss Nausea/vomiting Dizziness Lower levels of testosterone or decreased sperm levels Benefits Treatment of cancer Reduce side effects, promote tumor shrinkage, completely eradicate testicular cancer

4. Description of Treatment Delivery method: ointment applied directly to testicles The treatment will target cancerous cells of the testicles that have increased metabolisms The nanoparticles with competitive inhibitors for a cellular respiration enzyme will attach to and enter the cells and their mitochondria

5. Description of Treatment Nanoparticles with competitive inhibitors will inhibit the hexokinase enzyme that catalyzes the phosphorylation of glucose, therefore inhibiting cellular respiration and metabolism The competitive inhibitor will bind to the hexokinase active site, therefore inhibiting cellular respiration The cells will then die because they will be unable to make ATP and will not be able to survive

6. Trial Objectives and Purpose Goals: to determine… The efficacy of the treatment Any side effects the treatment presents Proper dosages Hypothesis: the Exovene treatment will successfully kill the cancerous cells by inhibiting cellular respiration and eradicate the testicular cancer This treatment is better than previous treatments because it can be applied directly to the affected area, will not affect any surrounding healthy cells, and will cause less discomfort for the patient.

7. Trial Design Double-Blind Trial One randomized group of 50 patients will receive one treatment, while the second randomized group of 50 patients will receive another treatment (based off strata of similar individuals) Treatments will randomly be assigned to each group One group receives Exovene treatment The other group receives a placebo

8. Selection of Subjects Criteria: Male Must be within age group (21 to 40 years old) Must be diagnosed with testicular cancer

9. Assessment of Safety Do not use except for the intended medical purpose Do not allow anyone else to use the ointment Use only on the patient’s testicles Do not go over or under in dosage (use with proper prescription)