1. DEVELOPMENT OF A SYSTEM FOR CONTROL OF BIOTECHNOLOGICAL PROCESSES ON THE BASIS OF DESIGNER Joint project between ICSR-BAS, Sofia, Bulgaria and Institute of Information Theory and Automation (UTIA)-Academy of Sciences of Czech Republic, Prague in the framework of bilateral Agreement on Scientific Co-operation between the Bulgarian Academy of Sciences and the Academy of Sciences of the Czech Republic Prague, September 2006

2. General control scheme Adaptive Controller Biotechnological process Estimators YY UY Y*  est Y

3. Biochemical model of Mixed culture for PHB production

4. Process reaction scheme

5. General Dynamical Model 11 22

6. Estimator of consumption rate  1,,

7. Estimator of consumption rate  2

8. Problem statement Adaptive Controller Biotechnological process Estimator  1 SS F S S* P P PP P* Estimator  2

9. Plan of investigations n Adaptive controller design by MIMO version of DESIGNER n Simulation investigations of the control scheme with different initial values of NH 3 n Simulation investigations of the control scheme with different set- points of dissolved oxygen concentration

10. Acknowledgments n This work was supported by : n The project in framework of bilateral agreements between Bulgarian Academy of Sciences and Academy of Science of Czech Republic. n Bulgarian National Fund “Scientific Researches” under contract No TH 1509/2005 where Ing. Miroslav Novak is a participant from Czech side

11. Thank you for your attention!