1. Research Priorities & Trends for NIH in 2003 Claire T. Driscoll Director Technology Transfer Office National Human Genome Research Institute (NHGRI) Research Institute (NHGRI) National Institutes of Health (NIH)

2. Changes in Organization of NIH 1960 to 2001* *Varmus, H., Science 291: 1903-1905, 2001.

3. The National Institutes of Health  27 Institutes, Centers and Divisions  Premiere biomedical research institution in U.S.  “The jewel in the crown of the federal government.”  In FY1999, the support of the American public, the Congress, and the Administration produced a commitment to double the funding for NIH by 2003 (=avg 15% increase every year for 5 years)  FY2003 budget: $27.3 Billion (not yet passed; FY03 started on Oct. 1, 2002)  FY2004 budget: est. 1-2% increase only

4.  “Many policy-makers may feel that the federal government has done its part for NIH-funded research and that the agency can be allowed to coast, aside from its bioterrorism research, at static levels of funding.”  “ The budget allocates 53% of the increase to NIAID, primarily to counter bioterrorism, and to NCI. Most other NIH institutes and centers would receive budget raises between 8 and 9%, which means that they would be managing a postdoubling research portfolio next year.” (e.g., FY’03) The NIH Budget in the "Postdoubling" Era Korn et al., Science (2002) 296: 1401-1402

5. Investments, Progress and Plans  Genomics Genomics Human Genetic Variation Cancer Diagnosis  Advanced Technologies Advanced Technologies Structural Genomics Response to Medicines  Disease Prevention, Diagnosis, and Treatment Disease Prevention, Diagnosis, and Treatment Early Cancer Detection AIDS  Training and Collaborative Research Training and Collaborative Research Computer Analysis of Biological Data Virtual Cell  Health Disparities Health Disparities Cancer Centers Diabetes in Minority Pop.  Health Education and Outreach Health Education and Outreach Human Genome Education Diabetes Outreach See www.nih.gov/about/investments.htmwww.nih.gov/about/investments.htm

6. Research Trends at NIH  Bigger Teams: complexity plus a need for specialists in areas other than biology including imaging, chemistry, computer science, mathematics, and informatics (=fewer projects/initiatives but w/larger budgets)  More clinical/translational research  New initiatives to either cross-train medical researchers in other scientific areas or help them collaborate with mathematicians, computer programmers, engineers and other types of scientists;  funding for various “Centers of Excellence” and key multi-site initiatives (research and pre-clinical testing services & clinical trial networks).

7. Doing Business with NIH  Small Business Office http://sbo.od.nih.gov/  e-Portals in Commerce System (e-PIC) http://epic.od.nih.gov/ virtual marketplace for all sizes and types of organizations to showcase promotional information, products and services  Contracts and Other Business Opportunities http://ocm.od.nih.gov/contracts/rfps/MAINPAGE.HTM  Small Business Funding Opportunities (including SBIR grants) http://grants1.nih.gov/grants/funding/sbir.htm#sbir

8. For more information:  Technology Transfer Office (TTO), NHGRI Building 12A Room 1033A tel: (301) 402-2537/ (301) 594-2235 e-mail: cdriscol@mail.nih.gov  http://www.nih.gov NIH home page http://www.nih.gov  http://www.genome.gov NHGRI technologies technology transfer information sources  http://ott.od.nih.gov All NIH technologies