1. 1 Competency test renal biopsy EM - Basic Drafted by Bart E Wagner Chief Biomedical Scientist Histopathology Department Northern General Hospital Sheffield S5 7AU Tel: 0114 – 2714154 Bart.wagner@sth.nhs.uk Draft date 12.03.2010

2. 2 1. Which pole of the glomerulus is this? 2. What is the plural of glomerulus? 3. Which pole of the glomerulus is this?

3. 3 1. What cell type is this? 2. What cell type is this? 3. What cell type is this?

4. 4 1. What cell type is this? 3. What cell type is this? 2. What cell type is this?

5. 5 1. What are these structures called? 2. What is this structure called? 3. What is these structures called?

6. 6 1. What is this organelle?

7. 7 2. What cell type is this? 3. What is this structure? 1. What is this structure? 4. What are these structures?

8. 8 Tubular epithelial cell 1. What is this organelle? 2. What is this organelle? 3. What is this organelle?

9. 9 2. What cell type is this? 1. What is this material? Renal interstitium

10. 10 1. What is this organelle? 2. What are these small round structures?

11. 11 1. What cell type is this? 2. What cell type is this? 3. What is the generic term for these cells?

12. 12 1. What cell type are these? 2. What type of chromatin is this? 3. What type of chromatin is this?

13. 13 1. What location are these deposits? 2. Histologically, using a silver stain, what would these be called?

14. 14 1. What location are these deposit?

15. 15 2. What is the location of this deposit? 1. What is the location of this deposit?

16. 16 1. What is the most likely nature of this fibrilary extracellular material? 2. What is the location of this material?

17. 17 1. What is this structure? 2. What did this cleft consist of?

18. 18 1. Why is it important to demonstrate that the altered GBM hasn’t affected just one loop? 2. How would you describe the changes seen in the GBM?

19. 19 1. What are these cells called? 2. What is this structure?

20. 20 1. Describe the mesangium.2. Describe the GBM.

21. 21 1. What type of vessel is this?2. What is this change referred to?

22. 22 Bowman’s capsule 1. What is this structure? 2. What is the name given to this intraglomerular epithelial cell? 3. How is this pathological state described histologically?

23. 23 Ruptured GBM 1. What is this material?

24. 24 1. Which organelle is affected in this cells? 2. Which cell type is overtly affected?