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ICC_MAN (n=3385 total processed MRI with M status ): min max mean median std range 25 quartile 50 quartile 75 quartile.

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Presentation on theme: "ICC_MAN (n=3385 total processed MRI with M status ): min max mean median std range 25 quartile 50 quartile 75 quartile."— Presentation transcript:

1 ICC_MAN (n=3385 total processed MRI with M status ): min max mean median std range 25 quartile 50 quartile 75 quartile

2 ICC_MAN (n=2746 total CLIMB): min971.27 max1876.24 mean1390.8 median1380.87 std136.44 range904.97 25 quartile 1294.04 50 quartile 1380.87 75 quartile 1480.08

3 ICC_MAN (n=2032 CLIMB with track period): min971.27 max1876.24 mean1388.9 median1378.55 std137.80 range904.97 25 quartile 1292.09 50 quartile 1378.55 75 quartile 1478.35

4 ICC_MAN (n=2032 CLIMB with track period):

5 ICC_MAN (n=2032 CLIMB with track period) TP'0''12''24''36''48''60''72''84''96''108''120' N 52935323822318717713079534320 MEANS 13941384139513931389 13861370138013891342 s ( StdErr) 679910 1215182131

6 ICC_MAN (n=923 CLIMB with track period) 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'1389.710.5042759.810 'Slope' 0.00450.02110.21360.8309 442 with 1 timepoint 482 with 2, 3, 4 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

7 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'1394.76140.92621505.8909 0 'Slope' 0.00450.02110.21360.8309 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints ICC_MAN (1590 tp n=482 CLIMB longitudinals with track period)

8 ICC_MAN_l (1590 tp n=482 CLIMB longitudinals with track period) Prediction plot

9 ICC_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

10

11 CSF_MAN (2746 total) : min53.34 max640.07 mean221.916 3 median213.705 std77.6252 range586.73 25 quartile 162.1 50 quartile 213.705 75 quartile 264.69

12 CSF_MAN (2032 with track period ): min54.91 max640.07 mean221.132 1 median212.345 std78.5487 range585.16 25 quartile 159.91 50 quartile 212.345 75 quartile 263.395

13 CSF_MAN (2032 with track period) TP0'12'24'36'48'60'72'84'96'108'120' N52935323822318717713079534320 MEANS218.757215.690220.224216.345226.271222.392228.438235.872241.926220.952224.561 StdErr 3.4144.1795.0905.2585.7425.9026.8878.83410.78511.97417.557

14 CSF_MAN (n=923 longitudinal CLIMB with track period), 442 with 1 timepoint 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'215.77650.852253.24940 'Slope' 0.13520.03573.78970.0002 442 with 1 timepoint 482 with 2, 3, 4 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

15 CSF_MAN (n=923 longitudinal CLIMB with track period) 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'212.50231.5672135.59580 'Slope' 0.13520.03573.78970.0002 482 with 2, 3, 4 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

16 BPF_MAN (2746 total) : min0.6589 max0.9595 mean0.8411 median0.857 std0.0505 range0.30006 25 quartile 0.8106 50 quartile 0.8457 75 quartile 0.8783

17 BPF_MAN (2032 with CLIMB track period): min0.6589 max0.9595 mean0.8415 median0.846 std0.051 range0.30006 25 quartile 0.8106 50 quartile 0.846 75 quartile 0.798

18 BPF_MAN (2032 with track period) TP0'12'24'36'48'60'72'84'96'108'120' N52935323822318717713079534420 m0.84420.84490.84250.84530.83770.84070.83530.82820.82530.84090.8323 s 0.00230.00270.00340.00350.00370.00350.00440.00550.00610.00690.0114

19 BPF_MAN (2032 MRI n=923 patients longitudinal CLIMB with track period) 442 with 1 tp 482 with multiple tps 234 with 2 tps 76 with 3 tps 57 with 4 tps 53 with 5 tps 41 with 6 tps 14 with 7 tps 6 with 8 tps 1 with 9 tps 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'0.84590.00061371.68030 'Slope' -0.00010-3.92970.0001

20 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'0.84830.0011749.58280 'Slope' -0.00010 -3.9319 0.0001 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints BPF_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

21 Individual Prediction plots

22 BPF_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

23 min0.2 max88.78 mean7.1807 median3.59 std9 range88.58 25 quartile 1.85 50 quartile 3.38 75 quartile 8.15 T2_MAN (2745 total) :

24 T2_MAN_climb (2032 with CLIMB track period): min0.2 max88.78 mean6.825 median3.465 std8.8286 range88.58 25 quartile 1.875 50 quartile 3.465 75 quartile 8.135

25 TP0'12'24'36'48'60'72'84'96'108'120' N52935323822318717713079534420 m6.63076.37376.82616.24436.67316.91778.170510.4765 6.296 5.7086 7.29 s 0.34350.40730.56150.5410.65290.70591.05381.64680.98740.96731.489 T2_MAN_l (2032 with track period)

26 T2_MAN (2032 MRI n=923 patients longitudinal CLIMB with track period) 442 with 1 tp 482 with multiple tps 234 with 2 tps 76 with 3 tps 57 with 4 tps 53 with 5 tps 41 with 6 tps 14 with 7 tps 6 with 8 tps 1 with 9 tps 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'6.53230.134548.57870 'Slope' 0.00520.00560.91630.3599

27 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'6.20480.247125.11070 'Slope' 0.00520.00560.92230.3568 234 with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints T2_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

28 Individual Prediction plots

29 T2_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

30 7365 (2002) 7366 - 0 (2003) 30448 -96 month (2011)33812 (2012) CLIMB dataset with track period 9 timepointsAvailable processed MRI Longitudinal dataset

31 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'1338.91791.8605719.6572 0 'Slope' -0.10180.1198-0.85020.4024 ICC longitudinal (1 dataset with 9 timepoints):

32 BPF longitudinal (1 dataset with 9 timepoints): 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'0.83410.0021398.58450 'Slope' -0.00020.0001-1.17320.2506

33 T2 longitudinal (1 dataset with 9 timepoints): 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'1.95840.043644.9070 'Slope' -0.00210.0028-0.74950.4598

34 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'1340.29131.4843902.9730 'Slope' -0.03160.0255-1.2390.222 ICC longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

35 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'0.85540.0018469.78720 'Slope' -0.00010-4.14450.0002 BPF longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

36 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept'2.97330.119724.84490 'Slope' 0.0070.00213.41830.0014 T2 longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

37 Dendrogram or hierarchical cluster tree X=[T2LV_MAN,BPF_MAN] Standardized Euclidean distance. Each coordinate in the sum of squares is inverse weighted by the sample variance of that coordinate. Linkage with inner squared distance (minimum variance algorithm)

38 Dendrogram or hierarchical cluster tree X=[T2LV_MAN,BPF_MAN] Mahalanobis distance. Each coordinate in the sum of squares is inverse weighted by the sample variance of that coordinate. Linkage with inner squared distance (minimum variance algorithm)

39 Plot Manova1 matrixManovacluster(stats) X=[Timepoint, BPF, T2, ICC]

40 Canonical analysis

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