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Pharmacotherapy in older age. Changes in pharmacokinetics and pharmacodynamics Polymorbidity, risk of DRUG-DISEASE interactions Polypharmacy, risk of.

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Presentation on theme: "Pharmacotherapy in older age. Changes in pharmacokinetics and pharmacodynamics Polymorbidity, risk of DRUG-DISEASE interactions Polypharmacy, risk of."— Presentation transcript:

1 Pharmacotherapy in older age

2 Changes in pharmacokinetics and pharmacodynamics Polymorbidity, risk of DRUG-DISEASE interactions Polypharmacy, risk of DRUG-DRUG interaction Self-sufficience? (vision, mobility of fingers) Social factors? COMPLIANCE

3 STOPP Criteria Screening Tool of Older People’s potentially inappropriate Prescriptions

4 START criteria „Screening Tool to Alert doctors to the Right Treatment“ an evidence-based screening tool to detect prescribing omissions in elderly patients—include: Antidepressant in the presence of clear-cut depressive symptoms lasting at least 3 months +0

5 START criteria an evidence-based screening tool to detect prescribing omissions in elderly patients include: Vitamin D and calcium ACE inhibitor in chronic heart failure, where no contraindication exists

6 START criteria an evidence-based screening tool to detect prescribing omissions in elderly patients—include: Warfarin in the presence of chronic atrial fibrillation, if there is no contraindication to warfarin +0

7 Pharmacotherapy in older age Start low, go slow! Polymorbidity a polypharmacy →consider benefits vs risks of each drug! STOPP & START


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