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MIBLab Workshop E-Cell Project 29 June, 2006
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E-Cell www.e-cell.org Model and reconstruct biological phenomena In silico Precise whole cell simulation
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Organization Headquarters - Institute for Advanced Biosciences, Keio University Original Home – Shonan-Fujisawa Campus, Keio University The Molecular Sciences Institute, Berkeley Mitsubishi Space Software Co. Ltd., Amagasaki
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History Project Launch – 1996 Cell model with 127 genes – 1997 Modeling real cells – 1998 The Institute for Advanced Biosciences – 2001
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Research Focuses Modeling methodologies E-Cell system Numerical simulation algorithms Mathematical analysis methods
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Research Group Mitochondrion E-Neuron E2coli e-Rice Erythrocyte Cell signaling –Bacterial chemotaxis signaling pathway –Stoch Sim algorithm Circadian rhythm, diabetes, mathematical analysis, myocardial cell
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E-Cell Parts E-Cell Simulation Environment (E-Cell SE) E-Cell Modeling Environment (E-Cell ME) E-Cell Analysis Toolkit
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System Features Object-oriented modeling and simulation Plug-in architecture Real-time user interaction and visualization
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Simulation Algorithms Gillespie Ordinary differential equations Differential-algebraic equations Power-law formalisms Flux distribution / discrete-time simulator
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Scripting Simulation session Analysis session Model file generation
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SBML / Parallel computation SBML level 1/2 import / export Parallel stepper scheduling (under development) Distributed computing
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Platforms Fedora core 3 Windows XP / 2000 (beta) RedHat Enterprise Linux on IBM pSeries Mandrake Linux 10 Future platforms –IBM AIX –Linux / x86-64 –Linux / IA64
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Tutorial Online tutorial (E-Cell Wiki) http://www.e-cell.org/community/tutorials ICSB 2006, Yokohama
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Simple Pathway Substrate (S) Enzyme (E) Product (P)
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Select Trace and Run
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Change Concentration and Run
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Modeling with E-Cell Entity (more than one) –Variable –Process –system Stepper
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EM Example
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Testing Result Pathway modeling tool A lot of numerical solvers XML model (EML) Cannot run other tools
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