1. The Cell Cycle Year 12 Biology C9

2. Draw a circle to the left hand side of the page

3. Divide the circle into four sections

4. Divide the right- hand quarter into fourths.

5. Label the quarters G1 Phase S Phase G2 Phase M PhaseM Phase M PhaseM Phase

6. Label the phases of M-phase (Mitosis) G1 Phase S Phase G2 Phase M PhaseM Phase M PhaseM Phase Prophase Metaphase Anaphase Telophase

7. Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

8. Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

9. Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

10. Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

12. Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

13. Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles

14. Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis

15. Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy

16. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Damage Cell big enough?

17. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Check for DNA Damage Cell big enough?

18. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Check for DNA Damage Cell big enough?

19. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Hold to break down cyclins Check for DNA Damage Cell big enough?

20. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Pause to break down cyclins Check for DNA Damage Cell big enough?

21. Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Pause to break down cyclins Check for DNA Damage Cell big enough?

22. Add external growth factors… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus

23. Nucleus makes internal regulators.. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus Kinase Cyclin

24. Nucleus makes internal regulators.. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus CDK complex

25. CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

26. CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

27. CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

28. CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

29. CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

30. CDKs start to break down… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

31. CDKs start to break down… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

32. Only when all CDK has broken down can the cell proceed to Metaphase… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy

33. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Only when all CDK has broken down can the cell proceed to Metaphase…

34. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy G0 phase At telophase the cell can go into G0 phase (and remain there) or continue on to the cell cycle…

35. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy G0 phase Differentiation The cell may then become differentiated into any one of the 200 body cells in humans..

36. Role of inhibitors… p27blocks the build up of CDK complex during G1 and prevents movement to S phase G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex p27

37. Role of inhibitors… p27blocks the build up of CDK complex during G1 and prevents movement to S phase p53 stops cell cycle at any point if DNA is damaged. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex p53

38. Role of inhibitors… If mutations occur to inhibitors – cancer may result i.e. uncontrolled cell cycle. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex