1. Please turn in the Unknown Solutions Lab Remember: We will vote on T-shirt designs on Monday

2. Chapter 5 Ligand gated ion channels, intracellular receptors and phosphorylation cascades

3. You Must Know The function of ligand gated ion channels, intracellular receptors and phosphorylation cascades.

4. ligand-gated ion channel Ions Plasma membrane Signaling molecule (ligand) 1 Gate closed Ligand-gated ion channel receptor © 2014 Pearson Education, Inc. Cellular response Gate open 2 Gate closed 3 Ions diffuse through the open channel

5. Steroid hormone interacting with an intracellular receptor. Only cells that contain receptors for the signal can respond to it. Plasma membrane Hormone (testosterone) EXTRA- CELLULAR FLUID © 2014 Pearson Education, Inc. Hydrophobic Plasma membrane Hormone- receptor complex Receptor protein Hormone (testosterone) EXTRA- CELLULAR FLUID Hydrophobic DNA Plasma membrane Hormone- receptor complex Receptor protein New protein Hormone (testosterone) mRNA EXTRA- CELLULAR FLUID CYTOPLASM NUCLEUS Hydrophobic Intracellular receptors

6. Figure 5.26 Phosphorylation cascade Inactive transcription factor NUCLEUS CYTOPLASM DNA mRNA Gene Active transcription factor Response Reception Transduction Receptor Growth factor © 2014 Pearson Education, Inc.

7. phosphorylation cascade Receptor Signaling molecule Activated relay molecule Inactive protein kinase 1 Phosphorylation cascade Inactive protein kinase 2 Active protein kinase 1 Active protein kinase 2 Active protein Inactive protein Cellular response ADP Protein phosphatases Protein kinase Protein kinases transfer phosphates from ATP to protein, a process called phosphorylation.

8. Figure 5.26 Phosphorylation cascade Inactive transcription factor NUCLEUS CYTOPLASM DNA mRNA Gene Active transcription factor Response Reception Transduction Growth factor Receptor © 2014 Pearson Education, Inc.