1. NormalFANCC B35B44 A1A2 Mendel’s Law of Independent Assortment HLA genes are linked: they do not sort independently through meiosis But the HLA locus on chromosome 6 and the Fanconi anemia locus on chromosome 9 do sort independently

2. Mitosis: all chromosomes line up at metaphase plate

3. Mitosis: sister chromatids separate in anaphase Two daughter cells are genetically identical to each other and to the parental cell

4. Meiosis: homologues pair and synapse in prophase I, then move to metaphase plate

6. Meiosis: anaphase I – 50% of meioses B44 A2 FANCC Normal B35 A1

7. Meiosis: anaphase I – 50% of meioses Normal B44 A2 FANCC B35 A1

8. Meiosis: anaphase II A1,B35 FANCC A1,B35 FANCC A2,B44 Normal A2,B44 Normal

9. Mendel’s law of independent assortment: Anaphase I Meiosis II Anaphase I Meiosis II B35 A1 B44 A2 B44 A2 B35 A1 B35 A1 B35 A2 B44 A2 B44 A1 B35B44 A2 A1 B35 B44 A2 Normal FANCC B35B44 A1A2 NormalFANCC B35B44 A1A2 Metaphase I  50% 50% 