1. End Show Slide 1 of 24 Copyright Pearson Prentice Hall 12-4 Mutations 12–4 Mutations

2. End Show 12–4 Mutations Slide 2 of 24 Copyright Pearson Prentice Hall 12-4 Mutations Mutations are changes in genetic material. –When cells make mistakes in copying their own DNA. –They do this by inserting an incorrect base or even skipping a base as a new strand is put together.

3. End Show 12–4 Mutations Slide 3 of 24 Copyright Pearson Prentice Hall Kinds of Mutations 1.Mutations that produce changes in a single gene are known as gene mutations. 2.Mutations that produce changes in whole chromosomes are known as chromosomal mutations.

4. End Show 12–4 Mutations Slide 4 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Gene Mutations Examples: 1.substitutions 2.insertions 3.deletions

5. End Show 12–4 Mutations Slide 5 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Substitutions (AKA Point mutation) usually affect no more than a single amino acid.

6. End Show 12–4 Mutations Slide 6 of 24 Copyright Pearson Prentice Hall Kinds of Mutations The effects of: insertions or deletions (AKA frameshift mutations) are more dramatic than substitutions!

7. End Show 12–4 Mutations Slide 7 of 24 Copyright Pearson Prentice Hall Kinds of Mutations In an insertion, an extra base is inserted into a base sequence.

8. End Show 12–4 Mutations Slide 8 of 24 Copyright Pearson Prentice Hall Kinds of Mutations In a deletion, the loss of a single base is deleted and the reading frame is shifted.

9. End Show 12–4 Mutations Slide 9 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Chromosomal Mutations Examples: 1.deletions 2.duplications 3.inversions 4.translocations

10. End Show 12–4 Mutations Slide 10 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Deletions involve the loss of all or part of a chromosome.

11. End Show 12–4 Mutations Slide 11 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Duplications produce extra copies of parts of a chromosome.

12. End Show 12–4 Mutations Slide 12 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Inversions reverse the direction of parts of chromosomes.

13. End Show 12–4 Mutations Slide 13 of 24 Copyright Pearson Prentice Hall Kinds of Mutations Translocations occurs when part of one chromosome breaks off and attaches to another.

14. End Show 12–4 Mutations Slide 14 of 24 Copyright Pearson Prentice Hall Significance of Mutations Many mutations have little or no effect on gene expression. Some mutations are the cause of genetic disorders. Polyploidy is the condition in which an organism has extra sets of chromosomes.

15. End Show - or - Continue to: Click to Launch: Slide 15 of 24 Copyright Pearson Prentice Hall 12–4

16. End Show Slide 16 of 24 Copyright Pearson Prentice Hall 12–4 A mutation in which all or part of a chromosome is lost is called a(an) a.duplication. b.deletion. c.inversion. d.point mutation.

17. End Show Slide 17 of 24 Copyright Pearson Prentice Hall 12–4 A mutation that affects every amino acid following an insertion or deletion is called a(an) a.frameshift mutation. b.point mutation. c.chromosomal mutation. d.inversion.

18. End Show Slide 18 of 24 Copyright Pearson Prentice Hall 12–4 A mutation in which a segment of a chromosome is repeated is called a(an) a.deletion. b.inversion. c.duplication. d.point mutation.

19. End Show Slide 19 of 24 Copyright Pearson Prentice Hall 12–4 The type of point mutation that usually affects only a single amino acid is called a.a deletion. b.a frameshift mutation. c.an insertion. d.a substitution.

20. End Show Slide 20 of 24 Copyright Pearson Prentice Hall 12–4 When two different chromosomes exchange some of their material, the mutation is called a(an) a.inversion. b.deletion. c.substitution. d.translocation.

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