1. Life and Medical Sciences Program lBiological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house. lGenomics: GTL Systems biology research in bioenergy, bioremediation and carbon sequestration; development of bioenergy research centers. lHealth Effects Research - Low Dose Radiation Program - Nuclear Medicine - Advanced bio-medical instrumentation - ELSI, Human Subjects Protection Program Office of Science U.S. Department of Energy

2. Shewenella Federation Comparative genomic and physiological analysis of Shewenella species. Functional genomics energy flow and electron transport. Genetic and functional characterization of c-type cytochromes Characterization and modeling of metabolic and regulatory networks. PNL, ANL,ORNL,USC,UCLA,MSU,BU. OU,MBL,DRI,BIATECH,GEONOMATICA

3. Federation Integrated Approach to Shewanella Biology Imaging AFM, EM, CLSM Immuno-EM Proteomics MS 2-D gel MR-1 Genome Sequence, Bioinformatics Information Synthesis & Interpretation Linked measurements Concepts & Hypotheses Cellular networks, Modeling Gene Expression Microarrays Reporters Physiology & Metabolism Computational Biology Data Analysis & Integration ▲ Perturbation: mutation cultivation ControlledCultivation

4. DOE Imaging Instrumentation Clinical PET MicroPET Mobile PET Office of Science U.S. Department of Energy

5. Awake Animal Project : The Rat CAP Miniaturized, novel electronics which allows the signals from the RatCAP to be collected, amplified and analyzed LSO crystal arrays, backed to photodiodes and electronics board. Image resolution comparable to micro-PET RatCAP MicroPET Schlyer, Vaska, Woody, 2006 Office of Science U.S. Department of Energy

6. Six 16-electrode devices implanted in humans. Longest implant in for 3 years. 60 electrode device completing pre-clinical testing in dogs. Human study scheduled for 12/06. Component design for 250 electrode device completed. ORNL, ANL, LANL, SNL, LLNL, BNL, USC, UC SC, CalTech,NC State, Second Sight