1. Process Control in Biomanufacturing Mary Jane Kurtz & George Taliadouros Minuteman Regional High School Bioman Conference July 2009

2. What is Process Control? Use of instruments to carry out a process Input information : measured variables temperature, oxygen, pH Output directions: manipulated variables heat, pressure gauge, valve

3. Motion and Process Control Motion control – position or velocity Process control – temperature, pressure, flow, level, pH,humidity, chemical compounds Two types of control of either of these –Batch processing –Continuous processing

4. Driving a Car: An Everyday Example of Process Control Control Objective Measured variable Manipulated variable (or controlled variable)‏ Sensor Actuator Controller Disturbance Maintain car in lane Location on the road Steering of car Driver’s eyes Driver’s arms/steering wheel Driver Curve in the road

5. Open Loop Control Valve controls flow of water: Open Loop

6. Closed Loop Control Control Process : Closed Loop

7. Process Control Diagram Error detector Error signal controller Controller output signal Actuator Energy or Fuel Manufacturing process Controlled variable Measured variable Disturbances Measurement devices Feedback Signal Set Point +-

8. Importance of Process Control for the Bio-Process Industries Improved product quality Faster and less expensive process validation Increased production rates

9. Biomanufacturing Tanks

10. DO Control in a Bio-Reactor

11. Controlling a Process Using Robolab you will learn how to control a process using a computer You will begin with a simple task : How to start and stop a fan How to control the variables in the process Finally, you will be create a program that will control a greenhouse

12. RBX Controls Inputs are measured variables seen as numbers Temperature sensor Touch sensor Light sensor Outputs are manipulated variables seen as letters Motor light

14. Time to Try it Out !!! Go to Robo Lab station and try to make a fan