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Training Translators for Smart Drug Discovery by Carsten Skarke, and Garret A. FitzGerald Sci Transl Med Volume 2(26):26cm12-26cm12 April 7, 2010 Published.

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Presentation on theme: "Training Translators for Smart Drug Discovery by Carsten Skarke, and Garret A. FitzGerald Sci Transl Med Volume 2(26):26cm12-26cm12 April 7, 2010 Published."— Presentation transcript:

1 Training Translators for Smart Drug Discovery by Carsten Skarke, and Garret A. FitzGerald Sci Transl Med Volume 2(26):26cm12-26cm12 April 7, 2010 Published by AAAS

2 Fig. 1. Physician-scientists at the helm. This case study demonstrates the scope of interactions involved in the pursuit of two mechanistic investigator-initiated protocols (clinicaltrials.gov identifiers NCT00682318 and NCT00780325). Carsten Skarke and Garret A. FitzGerald Sci Transl Med 2010;2:26cm12 Published by AAAS

3 Fig. 2. Modular, dis-integrated models of drug discovery and development. (Upper panel) Traditionally, the vertically integrated large pharmaceutical company retained expertise in target identification, medicinal chemistry, and clarification of the drugability of the target; pharmacokinetics and modeling; proof of concept (POC) in cells and model systems; and all phases Carsten Skarke and Garret A. FitzGerald Sci Transl Med 2010;2:26cm12 Published by AAAS

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