1. NCRR Tissue Project Example #4 Bioelectrical Tissue Characterization

2. NCRR Tissue Background Technology thrust Required by other projects Find common solutions to diverse problems Integration of basic technologies -Imaging -Modeling -Visualization -Analysis, morphometrics -Data management

3. NCRR Tissue Examples Brain tissue modeling DTI Conductivity Myocardial tissue modeling Conductivity Ischemia Microdomain models Electrical impedance tomography

4. NCRR Tissue Conductivity description on a organ/body level Body/Organ Level Heart with moving dipole layer (source) Detailed information on muscle fiber structure from diffusion tensor MRI What is conductivity/anisotropy of cardiac tissue ? Cellular Models I NaK I to I Kr I Ks I K1 I NaCa I pCa I Na I Na,b I Ca I Ca,b I K(ATP) Cardiac muscle cell What is a good model for the source ? Models of cardiac electrical activity

5. NCRR Tissue 123 epithelial cells cardiac cell capillaries 1 2 3 capillarymyocyte Rabbit heart Perfusion fluid with dye New Information Sources

6. NCRR Tissue Brain Structure - Fiber Tracks

7. NCRR Tissue Diffusion in Biological Tissue Motion of water through tissue Faster in some directions than others KleenexNewspaper Anisotropy: diffusion rate depends on direction isotropicanisotropic

8. NCRR Tissue Characterization of Brain Anatomy Park, Westin, and Kikinis, BWH, Harvard Medical School, 2003

9. NCRR Tissue Electrical Impedance Tomography

10. NCRR Tissue Tissue Characterization Technologies

11. NCRR Tissue The Future: Driving Science Volume conductor problems Torso, head models Whole organ models Heart, brain models Tissue models Myocardium, brain, tumors Cellular models Building blocks for higher orders

12. NCRR Tissue The Future: Technologies Imaging and Image processing Geometric modeling Visualization Data management Software infrastructure

13. NCRR Tissue The Future: Collaborations MGH NCRR Center SPL NCRR Center McVeigh imaging lab