1. Inflammation p.2 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Acute and Chronic Inflammation PBD (Pathologic Basis of Disease) Infectious Diseases

2. Inflammation p.2 109 Miliary tuberculosis 111 Tuberculous cavity of the lung 120 Actinomycosis 151 Sarcoidosis 241Enterobiasis (appendix) 123Trichinosis (muscle) 122 Cysticercosis (CNS)

3. „millet seed”- size (up to 2mm) TB granulomas: - giant Langhans cells - epithelioid cells - lymphocytes - caseous necrosis Miliary tuberculosis (lung)

4. Miliary tuberculosis

7. Tuberculous cavity of the lung the wall of a cavity: internal layer: - caseous necrosis middle layer: - components of TB granulomas outer layer: -granulation tissue -fibrous tissue

8. Tuberculous cavity of the lung please note: the micro-slide contains a fragment of a wall of a big TB cavity, don’t search for small cavities inside that specimen

9. Tuberculous cavity of the lung

11. Actinomycosis Actinomyces colonies surrounded by the purulent inflammtory infiltration

12. Actinomycosis

14. Sarcoidosis noncaseating granulomas composed of: - epithelioid cells, - Langhans cells - lymphocytes

15. Sarcoidosis

17. Enterobiasis (appendix) Tissue: - normal mucosa - or eosinophilic reaction - or acute appendicitis Worms: - distinctive lateral alae („thorns” in cross section) - sections may show eggs within worms (eggs may also be seen alone)

18. Enterobiasis (appendix)

20. Trichinosis (muscle) Worms: - encysted coiled roundworms Tissue: -muscle cells with inflammation including eosinophils and macrophages - fiber necrosis - larval death triggers eosinophilic granulomatous inflammation leading to calcification or - a chronic, inactive stage where encysted organisms are found in the absence of any cellular response.

21. Trichinosis (muscle)

23. Cysticercosis (CNS) Worm: - fluid-filled cyst with eosinophilic laminated wall lined by monolayer of rare nuclei - older lesions fibrotic and calcified Tissue: - little inflammation unless ruptured

24. Cysticercosis (CNS)