1. TIP has a safety and efficacy profile comparable with TIS, and offers a far more convenient treatment option for pseudomonas lung infection in CF. Konstan M et al. J Cyst Fibros Volume 10, Issue 1, January 2011, Pages 54–61Volume 10, Issue 1

2. Colistin Dry Powder for Inhalation demonstrated efficacy by virtue of non- inferiority to TIS in lung function after 24 weeks of treatment. There was no emergence of resistance of P aeruginosa to colistin. Overall, CDPI was well tolerated COLISTINA POLVERE INALATORIA

6. Canada >3,800 The international community is making a huge investment in future research: National CF registries Recent estimates of CF patients in registries world wide (2009-2012 data) USA >27,000 UK >9,500 New Zealand >400 Australia >3,100 Norway >250 Europe* >19,000 *- 20 countries, 10 of which have country registries