1. Human Papillomavirus (HPV)

2. Wed, Nov 21 2007 Tanjung Jaya, Indonesia

3. The Virus Papovaviridae infect skin and mucous membrane entry through clathrin mediated endocytosis to basal epithelia from micro-abrasions

4. Epidemiology modes of transmission is skin to skin, mucous membrane contact perinatal transmission (rare) causing respiratory papillomatosis 45% women at age 20-24, anyone sexually active is at risk

5. HPV types >100 subtypes, 30-40 STD high-risk type HPV 16, 18, 35, 45 – leads to cervical, vulva, vaginal cancer and other genitalia cancer including in men low-risk type HPV 6, 11 –causes genital warts cutaneous HPV 1,2 –skin warts

7. HPV type 16 and 18 cause nearly 70% of cases of cervical cancer HPV type 6 and 11 cause approx. 90% of genital warts Both 4 types cause 35-50% of all low grade cervical, vaginal and vulvar lesions

9. Diagnosis abnormal PAP smear HPV DNA testing (problem- expensive, cannot distinguish active or latent) acetic acid-warts more visible

11. Treatment and Prevention common skin and genital warts will regress spontaneously/ months/ years due to immune response common warts also can be eliminated using lasers vaccine Gardasil from Merck – approved June 2006 and Cervarix from GlaxoSmithKline –approved May 2007

12. ‘trick’ body into thinking that there is HPV infection thus generates immune response vaccine does not cure HPV, it prevents thus not suitable for infected patient, but not 100% prevention best prevention = vaccine + PAP smear annually (depends)

13. HPV in Malaysia cervical cancer is 2 nd most common cancer in women Gardasil has been approved during October 2006 MSD collaborate with OGSM to spearhead ‘Tell Someone’ campaign small figures for those who undergoes PAP smear each year

14. Reference HPV http://alpha.montclair.edu/~Williamss4/diagnosis.htm http://udel.edu/~jlaverty/Human%20Papilloma%20Virus.html#Pathogene sis__Symptoms http://en.wikipedia.org/wiki/Human_papilloma_virus#HPV_testing Cervical cancer is preventable 2007 http://www.redorbit.com/news/health/884330/cervical_cancer_is_preventa ble/index.html http://www.redorbit.com/news/health/884330/cervical_cancer_is_preventa ble/index.html ‘Tell Someone’ campaign in Malaysia http://www.msd- malaysia.com/content/corporate/about/news/2007/TellSomeone.htmlhttp://www.msd- malaysia.com/content/corporate/about/news/2007/TellSomeone.html Indonesia ‘Tree Man’ http://news.yahoo.com/s/nm/20071122/lf_nm_life/indonesia_tree_man_d c_1