1. S. pombe Unicellular archiascomycete Diverged from S. cerevisiae 330- 1144 Ma Size ~14 Mb, 3 chromosomes No synteny Data stored in GeneDB

2. Nomenclature Evolutionary relationships (orthology, paralogy, protein family and domain) Functional annotation (Using GO, from literature curation, functional transfer from orthologs, inferred electronically from protein family/domain) Genetic mapping data (minimal, small amount, mostly linked to physical sequence data) Areas of interest

3. Areas of expertise/collaborations Literature curation Ontology development (GO consortium) Ortholog/paralog resolution (and functional inference) Protein family identification (Pfam/Interpro) Functional mappings (e.g. Interpro2GO) Physical and genetic interactions (GO & BioGRID consortiums) Functional prediction (Daniel Barker)

4. Orthologs Sequence and annotation updates GO curation GO associations Domain /family Family identification Dataflow Links Interpro2Go GOA SPKW2GO 1 2 3 5 4 6 User submission Sequence analysis Literature curation Data mining

5. Biological process Cellular component Molecular function 101 124318 2681 494 537 106 Gene count 4990 Dubious 67 No GO S. pombe 567 11.5% (c.f. S. cerevisiae 612 10.5%)

6. GO terms S. cerevisiae orthologs Pfam families ** Submitted to Pfam 484 3161 272 41 38 27 532 ** DUF mainly eukaryotic/fungal No orthologs Of which 74 No S. cerevisiae ortholog Gene count 4990 Unassigned 456 Dubious 67 Conserved 57 No GO/Pf/Ort 341 ** Distant ortholog detection Pfam coverage S. pombe 75% c.f.S. cerevisiae 65%