1. T cell Maturation, Activation & Differentation
Hugh B. Fackrell

2. T cell Maturation, Activation & Differentation
Assigned Reading
Content Outline
Performance Ojectives
Key terms
Key Concepts
Short Answer Questions

3. Assigned Reading
Chapter: 12 pp
Janis Kuby’s Immunology 3rd Ed

4. Content Outline T Cell Maturation T helper Cell Activation
T Cell Differentiation
Peripheral gamma delta T cells

5. T Cell Maturation Pre T cell receptor T cell development pathways
Thymic Selection of T cells
positive selection
negative selection
T helper Cell Activation
TCR coupled signaling pathways
Co-stimulatory signal
Antagonists & Agonists
Clonal Expansion
Clonal Anergy
Superantigens

6. T Cell Differentiation
Effector & memory cells
Co-stimulatory differences

7. Peripherial  T cells Distribution of cells Ligands recognized
Functions

8. Performance Objectives

9. Key Terms
accessory molecules, antigen processing, associatve recogonition model,
independent recognition model, cell adhesion molecules,
subtractive hybrization

10. Key Concepts Outline antigen processing and presentation to TCR
Describe the molecular pathways for T cell activation
Describe positive and negative selection
Discuss the role of accessory molecules in T cell antigen recognition

11. Short Answer Questions

12. T cell proliferation and differentiation lead to important immunological functions. What are they?
Briefly discuss the molecular events, collected called T-Cell activation, that lead to biologic function.
What is the importance of diacylglycerol and IP3 in T-cell activation?
What transcription factors are involved in T cell activation?

13. DONE!!!