2. Date: January 26, 2016 Aim #49: How can mitosis lead to a disruption in homeostasis? HW: 1)Quarterly Exam Wednesday 1/27 (periods 1 & 7) and Thursday 1/28 (period 5) 2)LAB MAKE-UP DAY- Thursday AM & PM! 3)Plant Packet due Monday, February 1 st !!! (follow calendar of deadlines) Do Now: Warm-Up Notebook DateTitle of Activity Page # 1/26Let’s Draw the Stages of Mitosis! 84

3. Date: January 26, 2016 Aim #49: How can mitosis lead to a disruption in homeostasis? HW: 1)Quarterly Exam Wednesday 1/27 (periods 1 & 7) and Thursday 1/28 (period 5) 2)LAB MAKE-UP DAY- Thursday AM & PM ! 3)Plant Packet due Monday, February 1 st !!! (follow calendar of deadlines) Do Now: Warm-Up Notebook DateTitle of Activity Page # 1/26Name that Stage! 85

4. Aim#49: How can mitosis lead to a disruption in homeostasis?

5. What could have caused this? Cancer

6. Approximately 200 types Can you think of some? Lung cancerSkin cancer Breast cancer Prostate cancer

7. 1) Healthy cells Grow, divide, and replace themselves during the process of mitosis. Each mitotic division leads to the development of 2 NEW healthy cells.

8. How do cells divide by mitosis?

9. How is the cell cycle regulated? Controls on Cell Division –Experiments show that normal cells will reproduce until they come into contact with other cells. –When cells come into contact with other cells they respond by not growing. –This demonstrates that controls on cell growth and division can be turned on and off

10. How is the cell cycle regulated? Cell Cycle Regulators –The cell cycle is regulated by a specific protein. –The amount of this protein in the cell rises and falls in time with the cell cycle. –Scientists called this protein cyclin because it seemed to regulate the cell cycle. –Cyclins regulate the timing of the cell cycle in eukaryotic cells.

11. Check Points hhmi Biointeractive http://www.hhmi.org/bi ointeractive/eukaryotic -cell-cycle-and-cancer

12. 2) Abnormal cell division Sometimes, normal cells lose their ability to limit and direct their growth. They divide too rapidly and grow without any order.

13. What happens if cells are unable to regulate the cell cycle? Cancer is a disease that is caused by loss of control of the cell cycle. Cells continue to divide uncontrollably.

14. Cancer Cancer: uncontrolled cell division Tumors (lumps or masses of cancerous cells) will form as a result of this uncontrolled cell division. Tumors can be either malignant (spread - dangerous) or benign (can’t spread – safe)

15. Metastasis Cancer cells also can spread, to other parts of the body and form new tumors. How do they spread? They spread by using the circulatory system and lymph nodes.

16. 7) What causes cancer? Mutations - to genes, the cell's instructions for making the proteins it needs to survive, grow and multiply. Ultraviolet radiation Viruses Usually cancer is not inherited Carcinogens: chemicals Damage to the cells DNA from: Poor Diet Certain Pathogens (Viruses) Genetics UV Radiation (Sun) Drugs (Tobacco)

17. Anatomy of a Cigarette Smoking causes a third of all cases of cancer Cigarette smoke contains 3000 different chemicals, some of which are carcinogens. Some people have a lower risk of developing lung cancer. Their cells may be more efficient at repairing the gene damage caused by the carcinogens.

18. Lung Cancer: Healthy Lung Cancerous Lung

19. What is “x”?

20. 8) Treatment Surgery: physical removal of the malignant tumor Radiation: disrupts cell division Chemotherapy: drugs that prevent cell division by interfering with mitosis

21. Amoeba Sisters Cell Cycle and Cancer https://www.youtube.com/watch?v=lpAa4TWjHQ4