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Copenhagen, 5 March 2015 Identification of the most immunogenic/protective VLP-HA construct in mice Department of Immunology Development of a universal.

Published byBrandon Barrett Modified over 9 years ago

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Presentation on theme: "Copenhagen, 5 March 2015 Identification of the most immunogenic/protective VLP-HA construct in mice Department of Immunology Development of a universal."— Presentation transcript:

1 Copenhagen, 5 March 2015 Identification of the most immunogenic/protective VLP-HA construct in mice Department of Immunology Development of a universal influenza vaccine based on tandem core technology

2 Schematic of VLP-HA constructs Modified from Steel et al, mBio 2010 ΔHA stalk (HA 292-553 ): GGGG

3 VLP-HA constructs ΔHA stalk (HA 292-553 ): HA 292-351 : HA 306-474 : HA 403-474 : LAH (HA 420-474 ): HA 292-402 : HA 292-474 : HA 306-402 : HA 306-351 : HA 351-474 :

4 Immune response to VLP-HAs

5 Immunization with VLP-Has protects mice in vivo ΔHA stalk (HA 292-553 ): HA 306-474 : HA 403-474 : LAH (HA 420-474 ):

6 IgG-specific antibody response of mice vaccinated with VLP-HAs ΔHA stalk (HA 292-553 ): HA 306-474 : HA 403-474 : LAH (HA 420-474 ):

7 HA 420-474 (LAH) of different HA subtypes

8 Ongoing Work Immunization with new VLPs in mice In vivo challenge-protection assay with H3N2 Micro-neutralization and ADCC assays

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