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Consequences of Oversizing: Nerve-to-Nerve Tube Diameter Mismatch by Jonathan Isaacs, Satya Mallu, Wo Yan, and Barrett Little J Bone Joint Surg Am Volume.

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Presentation on theme: "Consequences of Oversizing: Nerve-to-Nerve Tube Diameter Mismatch by Jonathan Isaacs, Satya Mallu, Wo Yan, and Barrett Little J Bone Joint Surg Am Volume."— Presentation transcript:

1 Consequences of Oversizing: Nerve-to-Nerve Tube Diameter Mismatch by Jonathan Isaacs, Satya Mallu, Wo Yan, and Barrett Little J Bone Joint Surg Am Volume 96(17):1461-1467 September 3, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

2 Photographs made at time of the initial nerve repairs with the reversed autograft (group A) or with a 14-mm-long conduit of 3 mm (group B), 2 mm (group C), or 1.5 mm (group D) in diameter. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.

3 Photographs of examples of conduits from each group at the time of final testing and specimen harvest, three months after implantation. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.

4 Histologic specimens from three conduits (toluidine blue, 2×). Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.

5 Fig. 4 Bar graph demonstrating the mean contraction force (and standard deviation) of the reinnervated gastrocnemius muscle normalized with use of data from the control limb. *P < 0.05 compared with group A. #P < 0.05 compared with group B. Exp = experiment... Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.

6 Fig. 5 Bar graph displaying mean axon count (and standard deviation) for all groups compared with the control limbs. *P < 0.05 compared with the control limb. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.

7 Histological examples of sections from the experimental nerves (midpart of the graft or conduit) and control nerves from groups A though D twelve weeks after implantation (toluidine blue, 40×). Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96:1461- 1467 ©2014 by The Journal of Bone and Joint Surgery, Inc.


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