1. Principals of Biomedical Research Guri Tzivion, PhD tzivion@windsor.edu PBMR 611: Winter 2016 Windsor University School of Medicine

2. PBMR 611 course components: Frontal classes covering the key aspects of biomedical research conduct and scientific writing Frontal classes covering the key aspects of biomedical research conduct and scientific writing Journal club Journal club

3. Course Description Journal Club: The students will be divided to groups of 10 and assigned an instructor The students will be divided to groups of 10 and assigned an instructor 10 research papers will be assigned, covering all aspects of biomedical research, including basic, clinical and epidemiological research 10 research papers will be assigned, covering all aspects of biomedical research, including basic, clinical and epidemiological research Each student will present one paper Each student will present one paper All students are required to read the weekly papers and are expected to actively participate in group discussions All students are required to read the weekly papers and are expected to actively participate in group discussions

4. Course Description The Journal Club aims to: Train the students in critical reading of biomedical research papers Train the students in critical reading of biomedical research papers Provide a venue for discussing recent scientific advances in the biomedical research field Provide a venue for discussing recent scientific advances in the biomedical research field Improve the scientific communication skills of our students Improve the scientific communication skills of our students

5. Journal Club Presentation format: Introduction to the subject area: Introduction to the subject area:  General review of the subject  What was known before the authors started their work The declared hypothesis and objectives of the study The declared hypothesis and objectives of the study Methodologies used in the study Methodologies used in the study Results: Results:  Present the actual results of the study  Discuss each of the figures in detail

6. Journal Club Presentation format: Discuss the significance of the study and its contributions to advancing the subject area/field (as presented by the authors) Discuss the significance of the study and its contributions to advancing the subject area/field (as presented by the authors) Your critical analysis of the study: Your critical analysis of the study:  Strengths and weaknesses  If you were the reviewer of the paper, what would be your critique?

7. Journal Club Other points to consider in preparing your presentation: Have a simple title for each slide Have a simple title for each slide Fonts should be large enough to be seen clearly from the back of the room Fonts should be large enough to be seen clearly from the back of the room Figures: for multi-panel figures, enlarge and show each panel separately Figures: for multi-panel figures, enlarge and show each panel separately

8. Journal Club Presentation skills: Be familiar with the presentation content Be familiar with the presentation content Speak loudly and clear Speak loudly and clear Speak with excitement, don’t be monotone Speak with excitement, don’t be monotone Do not read the slides – use the text as reference Do not read the slides – use the text as reference Face the audience, make eye contacts Face the audience, make eye contacts Use body language (facial expression, gesture) Use body language (facial expression, gesture) Do not abuse the pointer Do not abuse the pointer

9. Student evaluations Block Exam 1: 25%. Will cover topics 1-2 and material from the journal club Block Exam 2: 25%. Will cover topics 3-4 and material from the journal club Journal Club Paper presentation: 35% 15%: instructor evaluation of student participation in journal club discussions

10. Journal Club Presentation evaluation grid: Familiarity with the subject (20%): Familiarity with the subject (20%): Presentation skills (20%): Presentation skills (20%): Stimulation of group discussion (20%): Stimulation of group discussion (20%): Preparedness (20): Preparedness (20): Overall presentation quality (20): Overall presentation quality (20): Final evaluation: Final evaluation: Comments for the student: Comments for the student:

11. Journal Club 1 st theme: longevity research and sirtuin activators 1.Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6. 2.Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42. 3.Hubbard BP and Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014 Mar;35(3):146- 54.

12. Journal Club 2 nd theme: B-Raf mutations and their targeting in Melanoma 4.Davies H, et al. Mutations of the BRAF gene in human cancer. Nature. 2002 Jun 27;417(6892):949-54. 5.Tsai J, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6. 6.Bollag G, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010 Sep 30;467(7315):596-9. 7.Sosman JA et al. Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib. N Engl J Med 2012; 366:707-714. Full text link: http://www.nejm.org/doi/full/10.1056/NEJMoa1112302

13. Journal Club 3 rd theme: Diabetes and high cholesterol management 8.Knowler WC, et al. "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin". The New England Journal of Medicine. 2002. 346(6):393-403 Full text link: http://www.nejm.org/doi/full/10.1056/NEJMoa012512 9.Patel A, et al. "Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes". The New England Journal of Medicine. 2008. 358(24):2560- 2572. Full text link: http://www.nejm.org/doi/full/10.1056/NEJMoa0802987 10. Kastelein JJ, et al. "Simvastatin with or without ezetimibe in familial hypercholesterolemia". The New England Journal of Medicine. 2008. 358(14):1431-1443. Full text link: http://www.nejm.org/doi/full/10.1056/NEJMoa0800742

14. Support Faculty Dr. Soumitra Chakravarty Biochemistry Dr. Vivek Joshi Biochemistry Dr. Bikramajit Singh Saroya Pathology Dr. Abiodun Mark Akanmode Pathology Dr. Baby Maloor Microbiology Dr. Samuel Taiwo Alawode Pre Med Program Dr. Osanoto Akolade Samuel Pre Med Program Dr. Uche Edith Amaefuna Behavioural Sciences